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Enhancement of Solubility and in vitro Drug Release Study for Lercanidipine Hydrochloride Loaded Liquid Self Nano Emulsifying Drug Delivery System using Factorial Design
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| Author:
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VIJAY GHORI, DASHARATH M.PATEL, ABDEL OMRI
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| Abstract:
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Almost 40% of the new drugs are hydrophobic in nature which draws attention towards SNEDDS to improve the oral bioavailability of such drugs. Lercanidipine HCl (LERCA), being a BCS class II drug having poor aqueous solubility presents a major challenge. The objective of present study was to formulate a liquid self nano emulsifying drug delivery system (L-SNEDDS) of LERCA that could improve its solubility, in vitro drug release and hence its oral bioavailability. The L-SNEDDS formulated and 32 full factorial design applied to study the effects of Capmul® MCM (X1), Polysorbate 20: Transcutol P(X2) on the % drug released (Y). The optimization was performed using the contour plot and was evaluated for various tests like solubility, Drug-surfactant compatibility, cloud point and in vitro diffusion, etc.The optimized formulation was found significant (P < 0.05) and showed drug release (96.19%) and infinite dilution capability. In vitro drug release of the optimized batch was high. The increase in drug release from L-SNEDDS may be attributed to the nano sized droplets and enhanced solubility of LERCA. FTIR suggests that there was no interaction between drug and excipients. It was observed that Polysorbate 20: Transcutol®P had a positive effect on % release i.e. % release increased with increase in Polysorbate 20: Transcutol®P ratio.The present work shows that SNEDDS can be formulated for better bioavailability for law aqueous soluble drug including LERCA. This was also proved statistically. LERCA can be further used for the preparation of various Solid SNEDDS formulation.
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| Keyword:
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Lercanidipine HCl (LERCA), Liquid self nano drug delivery system (L- SNEDDS), pseudo ternary phase diagram, In vitro diffusion
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| EOI:
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| DOI:
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