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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Enhanced transdermal/ topical delivery of acyclovir via solid lipid nanoparticles

Author: LAVAKESH OMRAY
Abstract: Solid lipid nanoparticles of acyclovir were prepared for the transdermal/ tropical delivery by ether injection method. The solid lipid nanoparticles were composed of acyclovir, glyceryl mono stearate, tween 60, soya lecithin, propylene glycol and double distilled water. Four different formulations were prepared which differed in the quantity of solid lipid. The solid lipid nanoparticles were characterized for various physicochemical parameters such as electron microscopy, particle size, polydispersity index, encapsulation efficiency, viscosity and in vitro release study. In vitro release kinetic also determined with the help of regression coefficients release study data. Selected formulation AR2 found to have 205 nm average size determined by Zeta sizer. Encapsulation efficiency was found to have 56.31%, which is reasonable well for solid lipid nanoparticles. Solid lipid nanoparticles was prepared for the purpose of topical application on the skin; therefore it should have enough viscosity. It was found 1960 cp in developed formulation.
Keyword: Solid lipid nanoparticles, acyclovir, transdermal, tropical, drug delivery
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0.12
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