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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Indion 414 as superdisintegrant in formulation of melt in mouth meloxicam tablets.

Author: UPLOADED BY-ADMIN, ASHOK KUMAR, A. G. AGRAWAL
Abstract: Melt in mouth tablets systems have carved a niche amongst the oral drug delivery systems due to the highest component of compliance they enjoy in patients especially the geriatrics and pediatrics. These delivery systems either dissolve or disintegrate in the mouth rapidly, without requiring any water to aid in swallowing so it is easy to take for any age patient, regardless of time or place. It is also easy to dose the aged, bed-ridden patients, or infants who have problems swallowing tablets and capsules. Indion 414 is a high-purity pharmaceutical grade ion exchange resin and is safe for oral consumption, cost-effective and is easily available. The present work was aimed to formulate and evaluate efficacy of Indion 414 as superdisintegrant in formulation of melt in mouth meloxicam tablets. FTIR spectra of meloxicam and Indion 414 was obtained to study the compatibility. Melt in mouth meloxicam tablets were prepared by direct compression method. The tablets were evaluated for hardness, percentage friability, weight variation, wetting time, water absorption ratio, in vitro dispersion time and percentage drug content. FTIR spectroscopy indicated that the drug is compatible with Indion 414. Formulations tested for all the official tests for tablets were found to be within limits. Indion 414 containing tablet gave in vitro dispersion time of 18s.
Keyword: Melt in mouth tablets, Indion 414, meloxicam, in vitro dispersion time, wetting time.
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0.12
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