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Indion 414 as superdisintegrant in formulation of melt in mouth meloxicam tablets.
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| Author:
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UPLOADED BY-ADMIN, ASHOK KUMAR, A. G. AGRAWAL
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| Abstract:
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Melt in mouth tablets systems have carved a niche amongst the oral drug delivery systems
due to the highest component of compliance they enjoy in patients especially the geriatrics
and pediatrics. These delivery systems either dissolve or disintegrate in the mouth rapidly,
without requiring any water to aid in swallowing so it is easy to take for any age patient, regardless
of time or place. It is also easy to dose the aged, bed-ridden patients, or infants who
have problems swallowing tablets and capsules. Indion 414 is a high-purity pharmaceutical
grade ion exchange resin and is safe for oral consumption, cost-effective and is easily available.
The present work was aimed to formulate and evaluate efficacy of Indion 414 as superdisintegrant
in formulation of melt in mouth meloxicam tablets. FTIR spectra of meloxicam
and Indion 414 was obtained to study the compatibility. Melt in mouth meloxicam tablets
were prepared by direct compression method. The tablets were evaluated for hardness, percentage
friability, weight variation, wetting time, water absorption ratio, in vitro dispersion
time and percentage drug content. FTIR spectroscopy indicated that the drug is compatible
with Indion 414. Formulations tested for all the official tests for tablets were found to be
within limits. Indion 414 containing tablet gave in vitro dispersion time of 18s.
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| Keyword:
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Melt in mouth tablets, Indion 414, meloxicam, in vitro dispersion time, wetting time.
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| DOI:
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