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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Studies on Antibacterial Potential of Asparagus racemosus Extract Against Bacteria Causing UTI

Author: DHARMVIR CHOUHAN, PRAGATI S. PANDEY
Abstract: ABSTRACT Urinary tract infection (UTI) is one of the commonest hospital acquired infection. It encompass a spectrum of clinical and pathological conditions involving various parts of the urinary tract. Despite treatment with antimicrobial agents, urinary tract infections are often recurrent. Either there is reinfection with a different micro-organism or recurrence of bacteriuria with the same organism that was originally isolated. A wide range of anti-microbials has been used to treat urinary tract infections. There is an increase in bacterial resistance in most patients and several infections have often proved to be therapeutically problematic. In recent times complementary and alternative medicine has taken an important role in treatment of various diseases. The objective of this study is to evaluate the antibacterial potential of the Asparagus racemosus ( Satawari ) on various multidrug resistant clinical isolates Four different extracts of Asparagus racemosus ( Satawari ) were screened for their antibacterial activity against multidrug resistant bacterial strains from patients with UTI. Aqueous, ethanolic, methanolic and ethyl acetate extracts of Asparagus racemosus ( Satawari ) were tested for antimicrobial activity in vitro by the agar well diffusion method. The minimum inhibitory concentration (MIC) of the effective extract was determined by the agar dilution method. Ethanolic extract of A. racemosus shown significant in vitro antibacterial activity against E. coli, Salmonella spp. as well as Pseudomonas aeruginosa while it is ineffective against Streptococcus spp. and S.aureus. Aqueous extract was found to be effective against both Gram positive as well as gram negative uropathogens. This extract is effective against Streptococcus spp., S.aureus spp., Salmonella spp., E. coli as well as Pseudomonas aeruginosa. Similarly, methanolic extracts result is also broad spectrum and showing activity towards gram positive as well as gram negative uropathogens. Similarly, ethyl acetate extract efficacy towards Salmonella spp., E. coli, Pseudomonas aeruginosa as well S.aureus but, it is ineffective against Streptococcus isolates. Result of antimicrobial assay reveals that methanolic and aqueous extract of plant exhibited broad spectrum activity against tested isolates as compared to ethanolic and ethyl acetate extract. This indicates that involvement of more than one active principles of biological significance. The herb A. racemosus is a safe drug with antimicrobial potential and without any known adverse effect might be an alternative to antibiotics during UTI infections.
Keyword: UTI, Asparagus racemosus, MDR
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