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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

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5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

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A Dietary Pattern including soluble fiber (ß- glucan) reduces prevalence of Metabolic Syndrome: A randomized, parallel group trial

Author: PRAGYA VERMA, PROF.RATAN K SRIVASTAVA, DR.DHARMENDRA JAIN
Abstract: Background: The Metabolic Syndrome (MS) is a cluster of abnormalities that is accompanied by a 2-fold increase in the risk of cardiovascular disease and has become a major public health concern throughout the world. Clinical trials using barley have shown the potential for a 10–15% reduction in LDL-C when it is added to a ‘heart-healthy’ diet. Most researches on soluble fibre (ß-glucan) have focused on oats, whereas barley another excellent source of this type of fibre but has received very little attention compare to oats. Objective: Thus the present study was designed to investigate whether the consumption of barley would reduce the prevalence of metabolic syndrome components. Design: A total of two hundred four men & women with Metabolic Syndrome aged 30–70 years, participated in a randomized parallel group design comparing a diet rich in soluble fiber ß-glucan (Intervention group) with a control diet ( control group)) of similar macronutrient composition but lacking barley. Both diets followed the National Cholesterol Education Program’s Adult Treatment Panel III NCEP (ATP III) STEP-I diet recommendations. The only difference between the two groups was the inclusion of fixed amount of barley food in the step-1 diet. Results: After the three month of active intervention 45.1% of the patients in the intervention group and 30.6% in the control group were no longer fulfilled the diagnostic criteria of metabolic syndrome. Prevalence of hyperglycemia and Hypertriglycerolemia decreased significantly in both the groups but barley diet was associated with a greater reduction in the prevalence of all components. At the end of trial significant difference were observed between the two groups regarding Hypertriglycerolemia and hyperglycemia. p<0.05 Conclusion: The results from this study suggested that barley intake has beneficial effects on risk factors for CVD. Therefore intake of a high-fiber food especially soluble fiber (ß-glucan) should be strongly recommended to prevent the burden of chronic diseases.
Keyword: Metabolic syndrome, cardiovascular risk factors, barley ß-glucan, Soluble fiber.
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Impact Factor for five years is 1.55 (2012 - 2016)

Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477