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Antidiarrhoeal activity of Launaea pinnatifida leaf juice in mice
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| Author:
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KAMALA CHANDAK, DIPAK D. WASULE, KAMLESH J. WADHER, MILIND J. UMEKAR
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| Abstract:
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Launaea pinnatifida has been traditionally claimed for its use in the treatment of diarrhoea. However, scientific support in relation to claim does not exist in any literature. The present study intended to investigate the antidiarrhoeal activity of the leaf juice of Launaea pinnatifida in mice using castor oil-, magnesium sulphate-, serotonin-, induced diarrhoeal tests in mice. Moreover, its effect on gastrointestinal tract transit was also evaluated by charcoal meal test. The results of the present experimentation demonstrated the antidiarrhoeal potential of Launaea pinnatifida leaf juice. The juice (250, 500 mg/kg, po) significantly reduced number of normal as well as diarrhoeal faecal output in castor oil-, magnesium sulphate-, serotonin-, induced diarrhoea and also significantly reduced the number of diarrhoeal episodes and these results were comparable with a standard antidiarrhoeal drug, loperamide. Both Launaea pinnatifida leaf juice and loperamide significantly reduced the gastrointestinal transit of charcoal meal in mice. The data obtained indicate that the Launaea pinnatifida leaf juice has both antidiarrhoeal and antipropulsive activities. However, further investigation on the mechanism of the antidiarrhoeal effect of the plant species needs to be carried out.
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| Keyword:
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Diarrhoea, Launaea pinnatifida, Castor oil, Magnesium sulphate, Serotonin, Charcoal meal gastrointestinal transit
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| DOI:
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