IJPR  articles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 1.55 (2012 - 2016). 

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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

ISSN
0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

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Antidiarrhoeal activity of Launaea pinnatifida leaf juice in mice

Author: KAMALA CHANDAK, DIPAK D. WASULE, KAMLESH J. WADHER, MILIND J. UMEKAR
Abstract: Launaea pinnatifida has been traditionally claimed for its use in the treatment of diarrhoea. However, scientific support in relation to claim does not exist in any literature. The present study intended to investigate the antidiarrhoeal activity of the leaf juice of Launaea pinnatifida in mice using castor oil-, magnesium sulphate-, serotonin-, induced diarrhoeal tests in mice. Moreover, its effect on gastrointestinal tract transit was also evaluated by charcoal meal test. The results of the present experimentation demonstrated the antidiarrhoeal potential of Launaea pinnatifida leaf juice. The juice (250, 500 mg/kg, po) significantly reduced number of normal as well as diarrhoeal faecal output in castor oil-, magnesium sulphate-, serotonin-, induced diarrhoea and also significantly reduced the number of diarrhoeal episodes and these results were comparable with a standard antidiarrhoeal drug, loperamide. Both Launaea pinnatifida leaf juice and loperamide significantly reduced the gastrointestinal transit of charcoal meal in mice. The data obtained indicate that the Launaea pinnatifida leaf juice has both antidiarrhoeal and antipropulsive activities. However, further investigation on the mechanism of the antidiarrhoeal effect of the plant species needs to be carried out.
Keyword: Diarrhoea, Launaea pinnatifida, Castor oil, Magnesium sulphate, Serotonin, Charcoal meal gastrointestinal transit
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Impact Factor for five years is 1.55 (2012 - 2016)

Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477