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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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SYNTHESIS AND BIOLOGICAL EVALUATION OF 2-AMINOBENZOTHIAZOLE DERIVATIVES

Author: AMIT SEMWAL, ARVIND NEGI, NARDEV SINGH
Abstract: A series of novel 2-Aminobenzothiazole derivatives were synthesized and evaluated for their anticonvulsant activity. These compounds were synthesized by the reaction of 2-Aminobenzothiazole with chloroacetylchloride in the presence of potassium carbonate in chloroform to synthesize 2-Chloro-N-(benzothiazol-2-yl)acetamide (AS), which was further reacted with various amines in the presence of potassium carbonate in acetone afforded target compounds (AS 1-12). All the newly synthesized compounds were screened for their anticonvulsant activity by Maximal Electroshock Seizure (MES) Model and subcutaneous pentylenetetrazol (scPTZ) Model.
Keyword: 2-Aminobenzothiazole, Chloroacetylchloride, Anticonvulsant activity.
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0.12
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