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SYNTHESIS AND BIOLOGICAL EVALUATION OF 2-AMINOBENZOTHIAZOLE DERIVATIVES
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| Author:
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AMIT SEMWAL, ARVIND NEGI, NARDEV SINGH
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| Abstract:
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A series of novel 2-Aminobenzothiazole derivatives were synthesized and evaluated for their anticonvulsant activity. These compounds were synthesized by the reaction of 2-Aminobenzothiazole with chloroacetylchloride in the presence of potassium carbonate in chloroform to synthesize 2-Chloro-N-(benzothiazol-2-yl)acetamide (AS), which was further reacted with various amines in the presence of potassium carbonate in acetone afforded target compounds (AS 1-12). All the newly synthesized compounds were screened for their anticonvulsant activity by Maximal Electroshock Seizure (MES) Model and subcutaneous pentylenetetrazol (scPTZ) Model.
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| Keyword:
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2-Aminobenzothiazole, Chloroacetylchloride, Anticonvulsant activity.
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| EOI:
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| DOI:
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| Download:
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