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Preparation, Characterization and In vitro Release Studies of Biodegradable Calcium Alginate - Diclofenac sodium Beads
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| Author:
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DHIREN SHAH, CHAINESH SHAH, KANA VARU
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| Abstract:
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In the current investigation, beads were prepared through ionotropic gelation. Different concentrations of cross-linking agent (CaCl2) were used for bead preparation and evaluated for various parameter like production yield, particle size, swelling behavior, encapsulation efficiency of Diclofenac sodium beads, and drug release kinetic. Formulation of Na-alginate (2.5% w/v) and Ca-chloride (1% w/v, 1.5% w/v, 2% w/v, 2.5% w/v, and 3% w/v) beads resulted in production yield in between the 25.65% to 69.19%. The particle size and shape of the beads were spherical uniform beads formed with the range of 1.09 to 1.14 (mm) in sizes. A swelling profile for beads in phosphate buffer (pH=7.4) was good as compared to HCL buffer (pH= 1.2), show the suitable nature of the beads. The encapsulation efficiency of the beads were found in between 42.98% to 90.52%.The drug release studies showed a rapid Diclofenac sodium release from the beads, principally those prepared from Na-alginate (2% w/v) and Ca-chloride (2% w/v), in phosphate buffer medium. In conclusion, Diclofenac sodium is capable of being microencapsulated as a bead formulation at optimal concentration of the cross linking agent as CaCl2 (2% w/v), with suitable properties and release profile.
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| Keyword:
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Beads, Ionotropic Gelation, Swelling behavior, Drug Release kinetic
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| EOI:
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| DOI:
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