IJPR  artciles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 1.55 (2012 - 2016). 

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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

ISSN
0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

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IJPRT ISSUE

January - March 6 [1] 2014

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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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PIPPHARMACON & IJPR 2018

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Article Detail

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Formulation and Evaluation of Colon Targeted Pulsincap of Lansoprazole – A Chronotherapeutic Approach

Author: PRASHANT BHIDE, NANDINI NAGESHKAR
Abstract: The aim of the present study was to develop colon targeted drug delivery system for Lansoprazole. Microspheres were prepared by ionotropic gelation method using sodium alginate and guar gum. The physicochemical characteristics of Lansoprazole microspheres were evaluated. Best formulation was selected for further preparation of hard gel capsules. The hydrogel plugs were punched using HPMC. Capsule bodies were made insoluble by formaldehyde treatment. The ‘pulsincap’ was evaluated for in vitro dissolution studies and drug release kinetics. Lansoprazole microspheres were spherical in nature and were confirmed by SEM studies. A maximum of 90% drug entrapment efficiency was obtained in Lansoprazole microspheres. The in vitro studies of Lansoprazole microspheres showed sustained action. The in vitro dissolution profile of Lansoprazole from modified pulsincap was in proportion to the concentration and viscosity of the polymer used in the hydrogel plug. The regression co-efficient values indicated that the release data fitted zero order kinetics.
Keyword: Lansoprazole, sodium alginate, guar gum, Pulsincap, colon targeted DDS, chronopharmaceutics.
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News & Events

2017: 6.457
2016: 5.999
2015: 5.406
2014: 5.099

CiteScore 2016 -  0.09

SJR 2016 - 0.111

SNIP 2016 - 0.055

Impact Factor for five years is 1.55 (2012 - 2016)
Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477
Impact Factor for five years is 1.3 (2010 - 2014)