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Synthesis of Substituted Sulfanyl 1H-Tetrazolyl Thiazolidinones
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| Author:
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DR RAMESH
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| Abstract:
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A process was developed for the synthesis of 3-(2-(1H-tetrazol-5-ylthio)ethyl) thiazolidine-2,4-dione (4) from 3-(2-bromoethyl)thiazolidine-2,4-dione (2) with an KSCN and NaN3. Then a series of substituted 3-(2-(1H-tetrazol-5-ylthio)ethyl) thiazolidine-2,4-diones (5a-5e) were prepared by treating (4) with suitable alkyl halides. The ambient conditions, excellent product yields, easy work up procedure and short reaction time makes this synthetic strategy a better protocol for the synthesis of title compounds (5a-5e). The structures of all the compounds were established on the basis of elemental and spectral (IR, 1H NMR and mass spectral data) studies.
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| Keyword:
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Potassium thiocyanate, dibromoethane, thiazolidinone, sodium azide, tetrazole
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| EOI:
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-
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| DOI:
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-
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| Download:
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