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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Cytotoxic potential of the crude solvent extract of Botryodiplodia theobromae – an endophytic fungi isolated from Catharanthus roseus.

Author: VARDHANA J, KATHIRAVAN GOVINDARAJAN
Abstract: Endophytes are microbes that colonize living, internal tissues of plants without causing any immediate negative effects. A large number of secondary metabolites have been extracted, isolated and characterized from endophytic microbes. In the present study, the medicinal plant Catharanthus roseus is used for the endophtyes isolation. The aim of this study is to extract secondary metabolites from Botryodiplodia theobromae, an endophytic fungi, isolated from Catharanthus roseus and to check the anti cancer potential of the solvent extract in MCF-7 and A549 cancer cell lines. The assay clearly evidenced that at the comcentration of 100 µl of the sample, there was a potent cytotoxic effect in the cancer cell lines. This study proves that active secondary metabolites can be extracted from endophytes, which proves to be a cost effective method for medical applications.
Keyword: Endophytes, Botryodiplodia theobromae, MCF-7, A549, Cytotoxicity, Secondary metabolites.
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