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Isolation of Fenugreek Seed Mucilage and Its Comparative Evaluation as a Binding Agent with Standard Binder.
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UPLOADED BY-ADMIN, VIDYA SABALE, VANDANA PATEL, ARCHANA PARANJAPE, PRAFULLA SABALE
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| Abstract:
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The objective of present investigation was to extract the mucilage from Fenugreek seeds and
to evaluate it as a binder for pharmaceutical dosage forms. Present work reports extraction of
mucilage from Fenugreek seeds. Fenugreek seed mucilage was extracted following the established
methods with little modifications. Mucilage was isolated from Fenugreek seeds by extraction,
soaking and boiling with double distilled water and precipitating by addition of acetone and
drying at 50-600 C under vacuum. The percentage yield of mucilage was 20-25% w/w. The physicochemical
characteristics of mucilage such as swelling index, solubility, loss on drying were
studied and pH was found to be 7.2 which is near to neutral value. The mucilage was evaluated
for its granulating and binding properties in tablets, using Ibuprofen as a model drug. Wet granulation
technique was used for preparation of granules using Fenugreek seed mucilage as a binder
at a concentration of 8%, 9% and 10% w/v. The prepared granules were evaluated for percentage
of fines, compressibility index and flow properties which were compared with starch as a standard
binder at a concentration of 10% w/v. The tablets were prepared and evaluated for content
uniformity, hardness, friability, disintegration time and in vitro dissolution profile. The tablets
had good physicochemical characteristics and drug release was found to be more than 85% within
three hours. The tablets prepared using 8% and 9% mucilage as binder could be considered as
ideal concentration for preparation of tablets than 10% concentration which exhibited more
hardness. Hence, Fenugreek seed mucilage (8% and 9%) has the potential for being substituted
as a binder for the more expensive starch in tablet formulation.
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| Keyword:
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Fenugreek, mucilage, tablets, binding agent, swelling index
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