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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Isolation of Fenugreek Seed Mucilage and Its Comparative Evaluation as a Binding Agent with Standard Binder.

Author: UPLOADED BY-ADMIN, VIDYA SABALE, VANDANA PATEL, ARCHANA PARANJAPE, PRAFULLA SABALE
Abstract: The objective of present investigation was to extract the mucilage from Fenugreek seeds and to evaluate it as a binder for pharmaceutical dosage forms. Present work reports extraction of mucilage from Fenugreek seeds. Fenugreek seed mucilage was extracted following the established methods with little modifications. Mucilage was isolated from Fenugreek seeds by extraction, soaking and boiling with double distilled water and precipitating by addition of acetone and drying at 50-600 C under vacuum. The percentage yield of mucilage was 20-25% w/w. The physicochemical characteristics of mucilage such as swelling index, solubility, loss on drying were studied and pH was found to be 7.2 which is near to neutral value. The mucilage was evaluated for its granulating and binding properties in tablets, using Ibuprofen as a model drug. Wet granulation technique was used for preparation of granules using Fenugreek seed mucilage as a binder at a concentration of 8%, 9% and 10% w/v. The prepared granules were evaluated for percentage of fines, compressibility index and flow properties which were compared with starch as a standard binder at a concentration of 10% w/v. The tablets were prepared and evaluated for content uniformity, hardness, friability, disintegration time and in vitro dissolution profile. The tablets had good physicochemical characteristics and drug release was found to be more than 85% within three hours. The tablets prepared using 8% and 9% mucilage as binder could be considered as ideal concentration for preparation of tablets than 10% concentration which exhibited more hardness. Hence, Fenugreek seed mucilage (8% and 9%) has the potential for being substituted as a binder for the more expensive starch in tablet formulation.
Keyword: Fenugreek, mucilage, tablets, binding agent, swelling index
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