IJPR  artciles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 1.55 (2012 - 2016). 

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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

ISSN
0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

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STABILITY INDICATING HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF DIPHENHYDRAMINE PHENYLEPHRINE PARACETAMOL DIAZEPAM IN BULK AND TABLET DOSAGE FORM

Author: MANGA KUNA, GOWRI SANKAR DANNANA
Abstract: Novel stability indicating RP-HPLC method has been developed and validated for simultaneous estimation of Diphenhydramine, Phenylephrine, Paracetamol and Diazepam in bulk and dosage forms. The method involves separation on BDS column (250mm*4.6mm*5µm particle size). The optimized mobile phase consists of 0.1% Ortho phosphoric acid and Acetonitrile (70:30 v/v) with a flow rate of 1 ml/min and UV detection at 211 nm. Retention time was 2.309 min for Diphenhydramine, 2.898 min for Phenylephrine, 3.304 min for Paracetamol and 9.769 min for Diazepam. RP-HPLC method for the simultaneous estimation of Diphenhydramine, Phenylephrine, Paracetamol and Diazepam in their combined dosage form was developed and validated as per the ICH guidelines. Linearity was observed in the range of 12.5-75µg/ml for Diphenhydramine, 6.25-37.5µg/ml for Phenylephrine, 125-750µg/ml for Paracetamol and 5-30µg/ml for Diazepam with correlation coefficients (r2=0.999). The percentage recoveries of Diphenhydramine, Phenylephrine, Paracetamol and Diazepam were in the range of 98.92-101.54% which was within the acceptance criteria. The %RSD was not more than 2% which proved the precision of the developed method. When applied for tablet assay, drug content was within 98.92-101.54% of labelled content. Forced degradation studies indicated the suitability of the method for stability studies.
Keyword: Diphenhydramine, Phenylephrine, Paracetamol, Diazepam
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News & Events

2017: 6.457
2016: 5.999
2015: 5.406
2014: 5.099

CiteScore 2016 -  0.09

SJR 2016 - 0.111

SNIP 2016 - 0.055

Impact Factor for five years is 1.55 (2012 - 2016)
Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477
Impact Factor for five years is 1.3 (2010 - 2014)