IJPR  articles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 1.55 (2012 - 2016). 

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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

ISSN
0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

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PREPARATION AND INVITRO CHARACTERISATION OF ANTIBACTERIAL NANOCAPSULES

Author: GAYATRI M, RAJESH AKKI, K. PRATHYUSHA
Abstract: Nanocapsules have been studied as carriers to deliver different types of drugs into macrophages. Many studies have shown that the nanocapsules can enhance the biological response of the drugs. In this study, The norfloxacin is an antibacterial agent. We prepared and evaluated Norfloxacin nanocapsules using K-Eudragit RL-100 polymer. The drug to polymer ratio on the particle size, encapsulation efficiency (EE %), zeta potential and the time required for 90% of norfloxacin to be released (t90%) was investigated. The selected drug loaded nanocapsules was subjected to further investigations including; Scanning electron microscope (SEM), and zeta potential. Moreover the antimicrobial effectiveness of the selected formula was investigated. The norfloxacin nanocapsules prepared have a mean diameter of 100 nm while the EE% ranged from 82-95%. In acid buffer at pH 1.2, high encapsulation rate was obtained. The selected formula retained its antimicrobial activity throughout the preparation process. The drug release from F2 formulation was found to zero order kinetics. It was also found linear in Higuchi’s plot which confirms that diffusion is one of the mechanisms of drug release.
Keyword: Novel drug delivery system, Nanocapsules, Norfloxacin, K-Eudragit RL-100, Nanocapsules Characterization
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Impact Factor for five years is 1.55 (2012 - 2016)

Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477