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PREPARATION AND INVITRO CHARACTERISATION OF ANTIBACTERIAL NANOCAPSULES
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| Author:
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GAYATRI M, RAJESH AKKI, K. PRATHYUSHA
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| Abstract:
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Nanocapsules have been studied as carriers to deliver different types of drugs into macrophages. Many studies have shown that the nanocapsules can enhance the biological response of the drugs. In this study, The norfloxacin is an antibacterial agent. We prepared and evaluated Norfloxacin nanocapsules using K-Eudragit RL-100 polymer. The drug to polymer ratio on the particle size, encapsulation efficiency (EE %), zeta potential and the time required for 90% of norfloxacin to be released (t90%) was investigated. The selected drug loaded nanocapsules was subjected to further investigations including; Scanning electron microscope (SEM), and zeta potential. Moreover the antimicrobial effectiveness of the selected formula was investigated. The norfloxacin nanocapsules prepared have a mean diameter of 100 nm while the EE% ranged from 82-95%. In acid buffer at pH 1.2, high encapsulation rate was obtained. The selected formula retained its antimicrobial activity throughout the preparation process. The drug release from F2 formulation was found to zero order kinetics. It was also found linear in Higuchi’s plot which confirms that diffusion is one of the mechanisms of drug release.
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| Keyword:
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Novel drug delivery system, Nanocapsules, Norfloxacin, K-Eudragit RL-100, Nanocapsules Characterization
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| EOI:
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| DOI:
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