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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

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0975-2366
5 - Years Impact Factor

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Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

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Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

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Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

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Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

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Development and Evaluation of Febuxostat Sublingual Tablet Formulation

Author: PRASHANT BHIDE, JUBEKA D’CUNHA, NASHOMA FERNANDES
Abstract: Febuxostat drug is recently developed for treatment of gout and classified under BCS class II. For treatment of gout, per-oral route is preferred route of administration, but first pass effect and poor bioavailability limits its application. To overcome these limitations efforts were made to enhance bioavailability of drug via development of sublingual tablet. The formulation was developed by direct compression method, where superdisintegrants like crospovidone, Kyron T-114®, sodium starch glycolate, croscarmellose sodium, Tulsion 339® and Indion 234® were used to enhance solubility and drug release rate. The tablets were evaluated for hardness, thickness, friability, weight variation, drug content, wetting time, in-vitro disintegration time, water absorption ratio and in-vitro dissolution studies. It was concluded that sublingual tablet containing Kyron T-114® and crospovidone showed the highest release (95.37%) at the end of 8 minutes. The optimized batch was subjected for accelerated stability studies. No change in physicochemical properties as well as in drug content and in-vitro release studies was observed.
Keyword: Febuxostat, gout, sublingual, superdisintegrants, solubility
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22nd National Convention of Society of Pharmacognosy & International Conference. For more details visit https://ncsp.ganpatuniversity.ac.in
Impact Factor for five years is 1.55 (2012 - 2016)
Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477
Impact Factor for five years is 1.3 (2010 - 2014)