IJPR  articles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 0.13 (2013 - 2018).    

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
Current Issue
Article In Press
No Data found.
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
 

Article Detail

Label
Label
Synthesis and Biological Evaluation of Some Quinolino Sulfonamides for Antimalarial and Antimicrobial Activity

Author: SHILPI SONKER, SHILPI SONKER
Abstract: A simple and regio-selective synthesis of new series of quinolino sulfonamides (4a-4e) and (4a’-4e’) were synthesized by the reaction of appropriate chalcones. The synthesized target compounds were screened for their anti-malarial activity using Vero cell line (C1008; Monkey kidney fibroblast) against Plasmodium falciparum (3D7 strain) with the standard and SI was measured by using IC50 and CC50 of tested compounds. The compounds 4a, 4d, 4c’ and 4e’ showed pronounced anti-malarial activity comparable to the reference standard Chloroquine diphosphate. Additionally, the synthesized compounds were evaluated for their in vitro antimicrobial activity against the representative panel of two gram positive, gram negative and antifungal strain. Four compounds 4a, 4c, 4b’ and 4c’showed considerable broad spectrum activity against all the tested Gram-positive and Gram-negative bacterial strains whereas 4a, 4d, 4c’ and 4e’ displayed significant antifungal activity.
Keyword: Chalcones, Sulfonamides, Antimalarial activity, Antimicrobial activity, Vero cell line (C1008; Monkey kidney fibroblast), SYBR Green-I (Invitrogen).
Download: Request For Article
 












ONLINE SUBMISSION
USER LOGIN


Username
Password
Login | Register
News & Events
SCImago Journal & Country Rank

Terms and Conditions
Disclaimer
Refund Policy
Instrucations for Subscribers
Privacy Policy

Copyrights Form

0.12
2018CiteScore
 
8th percentile
Powered by  Scopus
Google Scholar

hit counters free