IJPR  artciles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 1.55 (2012 - 2016). 

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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

ISSN
0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

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IJPRT ISSUE

January - March 6 [1] 2014

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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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PIPPHARMACON & IJPR 2018

PIPPHARMACON & IJPR 2018

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Synthesis and Biological Evaluation of Some Quinolino Sulfonamides for Antimalarial and Antimicrobial Activity

Author: SHILPI SONKER, SHILPI SONKER
Abstract: A simple and regio-selective synthesis of new series of quinolino sulfonamides (4a-4e) and (4a’-4e’) were synthesized by the reaction of appropriate chalcones. The synthesized target compounds were screened for their anti-malarial activity using Vero cell line (C1008; Monkey kidney fibroblast) against Plasmodium falciparum (3D7 strain) with the standard and SI was measured by using IC50 and CC50 of tested compounds. The compounds 4a, 4d, 4c’ and 4e’ showed pronounced anti-malarial activity comparable to the reference standard Chloroquine diphosphate. Additionally, the synthesized compounds were evaluated for their in vitro antimicrobial activity against the representative panel of two gram positive, gram negative and antifungal strain. Four compounds 4a, 4c, 4b’ and 4c’showed considerable broad spectrum activity against all the tested Gram-positive and Gram-negative bacterial strains whereas 4a, 4d, 4c’ and 4e’ displayed significant antifungal activity.
Keyword: Chalcones, Sulfonamides, Antimalarial activity, Antimicrobial activity, Vero cell line (C1008; Monkey kidney fibroblast), SYBR Green-I (Invitrogen).
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0.07
2017CiteScore
 
11th percentile
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Impact Factor for five years is 1.55 (2012 - 2016)
Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477