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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Evaluation of Antidiabetic Activity of Heterophragma quadriloculare (Roxb.) K. Schum. Leaves

Author: BHAVIKKUMAR SATANI, VILAS SURANA, SHAILESH SHAH, SHRI HARI MISHRA
Abstract: Introduction: Heterophragma quadriloculare (Roxb.) K. Schum. (HQ) belongs to Bignoneace family and known as Warras. Usage of HQ plant in diabetes has been claimed traditionally but scientific documentation is not yet available. So it was our interest to develop scientific database for HQ leaves. Materials and Methods: HQ leaves were studied for its traditional claim of antidiabetic activity by oral glucose tolerance test (OGTT) model using normal rats. All possible phytoconstituents were extracted into selected range of solvents based on its polarity i.e. petroleum ether, chloroform, methanol, water. The extracts were screened for OGTT at dose level of 200 and 400 mg/kg per oral. Subsequently petroleum ether extract (200 mg/kg), unsaponifiable fraction of petroleum ether extract (100 mg/kg) and saponifiable fraction of petroleum ether extract (100 mg/kg) of HQ were studied in rats by STZ-NAD induced type-II diabetic model up to 21 to find out most potent anti-diabetic fraction. Blood glucose and lipid profile were recorded on 0th and 21st day. Results and Discussion: In OGTT study though all extracts found to reduce blood glucose level, petroleum ether extract and chloroform extract showed dose dependent activity. These results provided the clue for presence of anti-diabetic constituents in petroleum ether extract. Oral administration of PEHQ and UPEHQ resulted in significant weight gain, reduction of blood glucose, serum cholesterol, serum VLDL and triglycerides in diabetic rats as compared to diabetic control rats. Unsaponifiable fraction of petroleum ether extract at the dose of 100 mg/kg showed significant antidiabetic activity. The present study thus justified the traditional claim of Heterophragma quadriloculare (Roxb.) K. Schum. for diabetes. Unsaponifiable fraction of petroleum ether extract of HQ needs further attention for separation and identification of biologically active compounds that are unidentified yet.
Keyword: Heterophragma quadriloculare (Roxb.) K. Schum, Antidiabetic, Oral Glucose Tolerance Test, Streptozotocin Nicotinamide induced type 2 Diabetes.
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