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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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INDUCTION OF APOPTOSIS AND CYTOTOXIC ACTIVITIES OF DEHYDROLEUCODINE USING IN VITRO MODELS

Author: SIDHHALINGESH PALLED, PRAMOD HJ
Abstract: Since skin cancer incidence and prevalence is constantly rising up the charts despite all efforts, search for newer, better agents for protection and treatment is required. Chemoprevention, which includes the use of synthetic or natural agents (alone or in combination) to block the development of cancer in human beings, is an extremely promising strategy for cancer prevention. Dehydroleucodine a sesquiterpene lactone was assessed for its anti-apoptotic effects in human epidermoid carcinoma A431 cells using the MTT assay and DNA fragmentation. Dehydroleucodine treatment exhibited considerable cytotoxicity as indicated by growth inhibition of A431 cells mediated via generation of reactive oxygen species (ROS) and subsequent induction of apoptosis.
Keyword: apoptosis, A431, cytotoxicity, skin cancer
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