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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

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0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

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Architecture of Viral RNA Helicases; HCV helicase as Antiviral Target

Author: SHILU MATHEW
Abstract: Around 80% of known viruses comprise of RNA and its specific RNA helicases that are vital for most RNA metabolism including pre-mRNA splicing, translation, initiation, and ribosome biogenesis. The viral helicases are crucial for the viral genome to replicate in the host as well as emerge as antiviral targets. With these vital properties, viral helicases have recently arisen as novel targets for the curing viral infections. DExH box protein (DECH variant) in HCV NS3 resembles SF2 family helicases which remarkably show high sequence similarity to Vaccinia virus nucleoside triphosphate phosphohydrolase II (NPH-II) as well as Plum pox virus (PPV) RNA helicase (DECH variant) cylindrical inclusion is a DExH box that consists of the Potyviridae polyprotein domain (PP). In this review, we highlight the importance of such motifs in the understanding of viral helicases with implications in inhibition properties. Strategies are discussed to identify novel inhibitors that would block these motifs, leading into probably new kind of antiviral compounds. Due to a limitation in treatment options including 1) interferon resistance and 2) the presence of high rate of resistance in anti-protease inhibitor classes, the helicase and anti-helicase targets for alternate attractions.
Keyword: ATP-dependent RNA Helicase, Hepatitis C/NS3 Helicase, Viral RNA Helicases, DExH/D box,
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Impact Factor for five years is 1.55 (2012 - 2016)

Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477