IJPR  artciles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 1.55 (2012 - 2016). 

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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

ISSN
0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

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IJPRT ISSUE

January - March 6 [1] 2014

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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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PIPPHARMACON & IJPR 2018

PIPPHARMACON & IJPR 2018

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THE ASSOCIATION AND LINKGAGE OF VARIOUS RETROVIRUSES AND ITS PROGRESSION TOWARDS NEURODEGENERATION

Author: SHILU MATHEW, MUHAMMAD FAHEEM, M. HAROON HAMED, SUGANTHY NATARAJAN, WAQAS IQBAL, GOVINDA ARJUNAN, KANEEZ FATIMA, ISHTIAQ QADRI
Abstract: ABSTRACT Effective prevention and treatment of infectious diseases has played an enormous role for the healthy outlook of human being. However at the same time, chronic ailments such as neurodegenerative diseases are on rapid rise, afflicting several hundred million individuals worldwide. The commonly known and studied diseases include Alzheimer’s disease, Parkinson’s, Huntington’s, Frontal Temporal Dementia, Multiple Sclerosis, Cerebral Palsy and Amyotrophic Lateral Sclerosis. In this review article we highlight the importance of viruses in the progression of various neurodegenerative diseases and cerebral palsy. The viruses included retroviruses, HSV-1, HSV-2, VZV, EBV, CMV, HHV-6, HHV-7, and HHV-8, members of the retroviruses, endogenous retrotranspsons and enteroviruses family. Viral gene and their interplay with the cellular machinery are also highlighted. The pathways that are perturbed by the viral infections are discussed and strategy is defined to combat such infections. Although there is no direct evidence that neurodegenerative diseases are caused by viruses, aberrant inflammatory reactions triggered by viral infections are critical determinant of neurodegeneration. This is predominantly preferential in individual with genetic mutations or epigenetic divergences that modulate the immune response or susceptibility to viral diseases. More specifically, we amalgamate concept that inflammation resulting from viral infections can initiate and propagate chronic neuronal dysfunction. In summary the therapeutic approaches to target immunological pathways of disease are presented to lower the incidence of neurodegenerative disorders and to create therapeutic opportunities for neuroprotection. Keywords: Neurodegenerative, Viruses, Therapeutic, Pathway
Keyword: Neurodegenerative, Viruses, Therapeutic, Pathway
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News & Events

CiteScore 2016 -  0.09

SJR 2016 - 0.111

SNIP 2016 - 0.055

Impact Factor for five years is 1.55 (2012 - 2016)
Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477
Impact Factor for five years is 1.3 (2010 - 2014)