IJPR  artciles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 1.55 (2012 - 2016). 

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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

ISSN
0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

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IJPRT ISSUE

January - March 6 [1] 2014

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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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PIPPHARMACON & IJPR 2018

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Synthesis and Biological Activity of Some Quinolino Pyrazole Derivatives

Author: SHILPI SONKER, DR.DEVENDERPATHAK
Abstract: A new series of pyrazole based quinoline were synthesized and evaluated for antimalarial and antibacterial activity. The rationale behind the synthesis of new series of quinolino pyrazoles (4a-4e) and (4a’-4e’) is in order to discover a new molecule which leads to dual anti-malarial–antimicrobial agents. The synthesized novel compounds were screened for their anti-malarial activity using Vero cell line (C1008; Monkey kidney fibroblast) against Plasmodium falciparum (3D7 strain) with the Chloroquine diphosphate and SI was measured by using IC50 and CC50 of compound. The results revealed that compounds 4c, 4e, 4a’ and 4e’ showed higher efficacies and potencies for anti-malarial activity comparable to the reference standard Chloroquine diphosphate. Additionally, the synthesized compounds were evaluated for their in vitro antimicrobial activity against two gram positive, gram negative and antifungal strain. Four compounds 4c, 4e, 4a’ and 4d’showed considerable broad spectrum activity against all the tested Gram-positive and Gram-negative bacterial strains as well as displayed significant antifungal activity.
Keyword: Chalcones, Pyrazoles, Sulfonamides, Plasmodium falciparum, Antimalarial activity, Antimicrobial activity, SYBR Green-I (Invitrogen)
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0.07
2017CiteScore
 
11th percentile
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Impact Factor for five years is 1.55 (2012 - 2016)
Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477