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Exploring Anticancer Potential of ZnO(NPs) in DMBA-Croton oil Induced Skin Carcinogenesis
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| Author:
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DEEPIKA JHANWAR, PROF. JAIMALA SHARMA
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| Abstract:
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This study was conducted to evaluate the antitumor effect of cationic ZnO nanoparticles (NPs) on 7, 12– Dimethylbenz(a)anthracene (DMBA) induced skin carcinogenesis in male Swiss albino mice.DMBA was applied on the shaved back of mice for the induction of tumor and then left for two weeks, after that Croton oil was applied thrice a week. In experimental mice ZnO (NPs) were applied along with Croton oil application and continued upto next 14 weeks. The effect of ZnO(NPs) on tumor growth was studied by Catalase (Cat) activity, Super oxide dismutase (SOD) activity, Reduced glutathione content(GSH),Vitamin C (Vit-C) content, Lipid peroxidation (LPO) and Total protein content in the skin. The SOD and catalase activities were found to be higher in the experimental animals (ZnO treated) as compared to only carcinogen treated positive control mice. The differences in the values of the results of experimental groups were statistically analyzed which were significant in comparison to the control group. The LPO in experimental groups significantly decreased as compared to the carcinogen treated control group. The GSH,vitamin C and total protein contents were comparatively higher in the ZnO(NPs) treated group. The results indicate chemopreventive and thearapeutic effects of ZnO (NPs) treatment.
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| Keyword:
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DMBA, ZnO nanoparticles, Lipid peroxidation, Catalase, Superoxide dismutase and Vitamin C.
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