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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

ISSN
0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

Current Issue
22nd NATIONAL CONVENTION

22nd National Convention of Society of Pharmacognosy & International Conference. For more details visit


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Article In Press
Biomechanical/biochemical factors contributing to cardiac fibrosis in the heart and engineered cardiac tissue
THE ASSOCIATION AND LINKGAGE OF VARIOUS RETROVIRUSES AND ITS PROGRESSION TOWARDS NEURODEGENERATION
Architecture of Viral RNA Helicases; HCV helicase as Antiviral Target
GC-MS analysis of rhizome extract by Cold maceration of Curcuma amada Roxb.
Development and Evaluation of Febuxostat Sublingual Tablet Formulation
Development and Evaluation of Febuxostat Sublingual Tablet Formulation
A comparative study of adaptogenic effect of Withania somnifera with Mifepristone (a GR antagonist) on chronic stress - induced perturbations in glucose metabolism
In Vitro Anticancer Activity Of Leaves Of Rumex Vesicarius Linn And Symplocos Racemosa Roxb By Trypan Blue Method
PREPARATION AND INVITRO CHARACTERISATION OF ANTIBACTERIAL NANOCAPSULES
Cytotoxic potential of the crude solvent extract of Botryodiplodia theobromae – an endophytic fungi isolated from Catharanthus roseus.
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IJPRT ISSUE

January - March 6 [1] 2014

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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Article Detail

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Exploring Anticancer Potential of ZnO(NPs) in DMBA-Croton oil Induced Skin Carcinogenesis

Author: DEEPIKA JHANWAR, PROF. JAIMALA SHARMA
Abstract: This study was conducted to evaluate the antitumor effect of cationic ZnO nanoparticles (NPs) on 7, 12– Dimethylbenz(a)anthracene (DMBA) induced skin carcinogenesis in male Swiss albino mice.DMBA was applied on the shaved back of mice for the induction of tumor and then left for two weeks, after that Croton oil was applied thrice a week. In experimental mice ZnO (NPs) were applied along with Croton oil application and continued upto next 14 weeks. The effect of ZnO(NPs) on tumor growth was studied by Catalase (Cat) activity, Super oxide dismutase (SOD) activity, Reduced glutathione content(GSH),Vitamin C (Vit-C) content, Lipid peroxidation (LPO) and Total protein content in the skin. The SOD and catalase activities were found to be higher in the experimental animals (ZnO treated) as compared to only carcinogen treated positive control mice. The differences in the values of the results of experimental groups were statistically analyzed which were significant in comparison to the control group. The LPO in experimental groups significantly decreased as compared to the carcinogen treated control group. The GSH,vitamin C and total protein contents were comparatively higher in the ZnO(NPs) treated group. The results indicate chemopreventive and thearapeutic effects of ZnO (NPs) treatment.
Keyword: DMBA, ZnO nanoparticles, Lipid peroxidation, Catalase, Superoxide dismutase and Vitamin C.
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News & Events
22nd National Convention of Society of Pharmacognosy & International Conference. For more details visit https://ncsp.ganpatuniversity.ac.in
Impact Factor for five years is 1.55 (2012 - 2016)
Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477
Impact Factor for five years is 1.3 (2010 - 2014)