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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

ISSN
0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

Current Issue
22nd NATIONAL CONVENTION

22nd National Convention of Society of Pharmacognosy & International Conference. For more details visit


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Article In Press
Biomechanical/biochemical factors contributing to cardiac fibrosis in the heart and engineered cardiac tissue
THE ASSOCIATION AND LINKGAGE OF VARIOUS RETROVIRUSES AND ITS PROGRESSION TOWARDS NEURODEGENERATION
Architecture of Viral RNA Helicases; HCV helicase as Antiviral Target
GC-MS analysis of rhizome extract by Cold maceration of Curcuma amada Roxb.
Development and Evaluation of Febuxostat Sublingual Tablet Formulation
Development and Evaluation of Febuxostat Sublingual Tablet Formulation
A comparative study of adaptogenic effect of Withania somnifera with Mifepristone (a GR antagonist) on chronic stress - induced perturbations in glucose metabolism
In Vitro Anticancer Activity Of Leaves Of Rumex Vesicarius Linn And Symplocos Racemosa Roxb By Trypan Blue Method
PREPARATION AND INVITRO CHARACTERISATION OF ANTIBACTERIAL NANOCAPSULES
Cytotoxic potential of the crude solvent extract of Botryodiplodia theobromae – an endophytic fungi isolated from Catharanthus roseus.
12
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IJPRT ISSUE

January - March 6 [1] 2014

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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Article Detail

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FORMULATION AND INVITRO EVALUTION OF EFFERVESCENT FLOATING TABLETS OF LOSARTAN POTASSIUM BY USING DIFFERENT GRADES OF HPMC POLYMERS

Author: RAJESH AKKI, M GAYATRI RAMYA
Abstract: Objective: The Losartan potassium effervescent tablets were prepared using different grades of HPMC polymers (HPMC K4M, HPMCK15M, HPMCK100M) in different ratios for prolonging the gastric residence time, improve the bioavailability of the drug and to improve the patient compliance. Method: The losartan effervescent floating tablets were prepared by direct compression method. The losartan effervescent floating tablets were evaluated for hardness, friability, weight variation, drug content, in vitro buoyancy studies like floating lag time, total buoyancy time, swelling index and in vitro dissolution studies. The drug and polymer compatibility was evaluated by FTIR study. Results: All the batches showed compliance with pharmacopoeia standards. Formulation F4 containing HPMC K4M in 1:2 ratio showed controlled drug release for 12hr(99.35%) emerging as best formulation. Among all the formulations formulation F4 which contains HPMC K4M in 1:2 ratio releases the drugs which follow zero order kinetics via, swelling, diffusion. Percentage swelling index studies reveals that as increasing polymer concentration percentage swelling index was also increased. An in vitro buoyancy study reveals that all batches showed good floating properties. The FTIR study reveals that there was no interaction between Losartan potassium and polymers. Conclusion: different grades of HPMC polymers such as HPMC K4M, HPMC K15M, HPMC K100M can be used to prepare effervescent floating tablets for prolonging the gastric residence time, improve the drug absorption and improve the patient compliance.
Keyword: Losartan potassium, effervescent floating tablet, HPMC K4M, HPMC K15M, HPMC K100M, controlled release
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News & Events
22nd National Convention of Society of Pharmacognosy & International Conference. For more details visit https://ncsp.ganpatuniversity.ac.in
Impact Factor for five years is 1.55 (2012 - 2016)
Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477
Impact Factor for five years is 1.3 (2010 - 2014)