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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

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FORMULATION AND INVITRO EVALUTION OF EFFERVESCENT FLOATING TABLETS OF LOSARTAN POTASSIUM BY USING DIFFERENT GRADES OF HPMC POLYMERS

Author: RAJESH AKKI, M GAYATRI RAMYA
Abstract: Objective: The Losartan potassium effervescent tablets were prepared using different grades of HPMC polymers (HPMC K4M, HPMCK15M, HPMCK100M) in different ratios for prolonging the gastric residence time, improve the bioavailability of the drug and to improve the patient compliance. Method: The losartan effervescent floating tablets were prepared by direct compression method. The losartan effervescent floating tablets were evaluated for hardness, friability, weight variation, drug content, in vitro buoyancy studies like floating lag time, total buoyancy time, swelling index and in vitro dissolution studies. The drug and polymer compatibility was evaluated by FTIR study. Results: All the batches showed compliance with pharmacopoeia standards. Formulation F4 containing HPMC K4M in 1:2 ratio showed controlled drug release for 12hr(99.35%) emerging as best formulation. Among all the formulations formulation F4 which contains HPMC K4M in 1:2 ratio releases the drugs which follow zero order kinetics via, swelling, diffusion. Percentage swelling index studies reveals that as increasing polymer concentration percentage swelling index was also increased. An in vitro buoyancy study reveals that all batches showed good floating properties. The FTIR study reveals that there was no interaction between Losartan potassium and polymers. Conclusion: different grades of HPMC polymers such as HPMC K4M, HPMC K15M, HPMC K100M can be used to prepare effervescent floating tablets for prolonging the gastric residence time, improve the drug absorption and improve the patient compliance.
Keyword: Losartan potassium, effervescent floating tablet, HPMC K4M, HPMC K15M, HPMC K100M, controlled release
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Impact Factor for five years is 1.55 (2012 - 2016)

Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477