Impact Factor for Five Years is 1.55 (2012 - 2016). 22nd National Convention of Society of Pharmacognosy & International Conference. For more details visit https://ncsp.ganpatuniversity.ac.in/index.php

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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

ISSN
0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

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Antioxidant activity and total phenolic content in 15 commonly used cucurbits in Tarai region of Kumaun, Uttarakhand.
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Role of NMDA receptor antagonist in ethanol withdrawal syndrome
STABILITY INDICATING LC-MS/MS METHOD FOR QUANTIFICATION OF IBRUTINIB IN HUMAN PLASMA
A review on drug: Amantadine
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ROLE OF AMIODARONE IN ACUTE MYOCARDIAL INFARACTION INDUCED VENTRICULAR TACHYCARDIA IN PATIENTS WITH LEFT ANTERIOR DESCENDING ARTERY INVOLVEMENT
Extraction optimisation, fractionation, standardisation, in vitro antioxidant and anticholinesterase activity of fractions of Indian Propolis
Development of validated stability-indicating analytical method for simultaneous estimation of Atenolol and Hydrochlorothiazide in pharmaceutical combined dosage form by High Performance Thin Layer Chromatography.
Lung Cancer in Lifelong Never Smokers-Short Review
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IJPRT ISSUE

January - March 6 [1] 2014

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Article Detail

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3D-Quantitative Structure Activity Relationship Study of Pyrazolothiazol-4-(5H)-One Derivatives as Epidermal Growth Factor Receptor Inhibitors

Author: DEEAPLI JAGDALE, MAHESH KHARATMOL, PRIYANAKA GANDHI, PRIYANKA GAIKWAD, NEHA NANDEDKAR
Abstract: Pyrazolothiazol-4-(5H)-one derivatives were synthesized and studied for in vitro anti-cancer activity on cell line MCF-7 which is known to over-express epidermal growth factor receptor (EGFR). EGFR is considered as a good target for chemotherapeutic intervention. Three-dimensional quantitative structure activity relationship (3D-QSAR) approach became very useful and largely widespread technique for ligand-based drug design. In this paper, an attempt was made to develop a 3D-QSAR study on a series of pyrazolothiazol-4-(5H)-one derivatives acting as protein tyrosine kinase (EGFR) inhibitors. The study has been carried out using VLife MDS 4.6.1 software. The stepwise 3D-QSAR kNN-MFA method was applied to derive QSAR model. The information rendered by 3D-QSAR model may lead to a better understanding and designing of novel EGFR inhibitor molecules. 3D-QSAR is an important tool in understanding the structural requirements for design of novel, potent and selective EGFR inhibitors. Thus, the present work can be employed for new drug discovery and can be used in future for designing novel derivatives of pyrazolothiazol-4-(5H)-one with higher EGFR inhibitory activity.
Keyword: EGFR inhibitors, stepwise 3D-QSAR, kNN-MFA model, pyrazolothiazol-4-(5H)-one derivatives.
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22nd National Convention of Society of Pharmacognosy & International Conference. For more details visit https://ncsp.ganpatuniversity.ac.in
Impact Factor for five years is 1.55 (2012 - 2016)
Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477
Impact Factor for five years is 1.3 (2010 - 2014)