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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Formulation and Evaluation of Microencapsulated Suspension of Ofloxacin

Author: JYOTHIRMAI CHIKKALA
Abstract: Ofloxacin is an anti infective drug used for the treatment of lower respiratory tract infections, skin infection and urinary tract infections. It is extremely bitter in taste and short half life. The purpose of present research work was, taste should be masked to formulate it in a palatable form and formulate in sustained release formulation to increase bioavailability. Formulate tasteless complexes of Ofloxacin with Indion 204 ion exchange resin. The resinates are formulated as suspension with sustained release polymer. The developed suspension is evaluated for taste masking and sustained release. The results showed that Ofloxacin was successfully taste masked and formulated into taste masked sustained release suspension formulation.
Keyword: Ofloxacin, Indion 204, Drug-resinate, Microencapsulation, Taste masking, Suspension.
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