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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Influence of Ethylcellulose on Dissolution Profile of Carbamazepine Cyclodextrin Complex

Author: GHANSHYAM PARMAR, GANDHI K S, SAILOR G U, CHAUHAN S P, SETH A K
Abstract: Carbamazepine (CBZ), a BCS class II drugs used in treatment of trigeminal neuralgia.The present study was carried out to prepare and characterize extended-release matrix tablets of CBZ using ethylcellulose (EC) as a polymer and drug was solubilized by manufacturing inclusion complex with ?-cyclodextrin (?-CD). First, inclusion complex were prepared with ?-CD and then, tablet were prepared with EC. The tablet were formulated by keeping the 1:3 drug: ?-CD ratio constant but varying drug: polymer ratio (1:1, 1:1.5, 1:2, 1:2.5, 1:3, 1:3.5).The in-vitro drug release study revealed that either EC preparation was able to extend the drug release only for 24 hours. The CBZ: ?-CD complex improve the solubility and thus improve the dissolution profile of CBZ.These results suggested that the tablet formulated using EC as a drug retarding polymers could be advantageous than conventional CBZ tablets.
Keyword: Extended Release; Carbamazapine; ?-cyclodextrin; Ethyl cellulose; Inclusion complex
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