IJPR  articles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 0.13 (2013 - 2018).    

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
Current Issue
No Data found.
Article In Press
No Data found.
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
 

Article Detail

Label
Label
Formulation and Evaluation of Ketoprofen Loaded Transdermal Drug Delivery.

Author: UPLOADED BY-ADMIN, SOMASHEKHARA C.N, K.GOWTHAMARAJAN, D.V.GOWDA, RAJESH. N, SIDDARAMAIAH
Abstract: The potential applications of highly biocompatible of Transdermal drug delivery system (TDDS) as a tropical drug carrier system for the percutaneous delivery of Ketoprofen. TDDS films were prepared by using Hydroxy Propyl Methyl Cellulose(HPMC) and Polyethylene glycol 400 (PEG-400) by varying the blend ratios viz., 10:0, 8:2, 6:4, 4:6 and 2:8 (w/w %). The drug loaded membranes were evaluated for thickness, tensile behaviors, content uniformity, in-vitro drug release studies and skin irritation test effect. Dimethyl sulfoxide (DMSO) was used to evaluate the percutanious enhancing effect. Ketoprofen was found to be compatible and stable with the prepared formulation as confirmed by Fourier transform infrared (FTIR) and Differential Scanning Calorimetry (DSC), studies. In-vitro release studies showed a controlled release for 8h. Skin irritation test reveals no signs of erythema, edema or ulceration. From the present study it can be concluded that, the prepared transdermal films can be used to achieve controlled release of the drug and showed good skin tolerability.
Keyword: Ketoprofen, HPMC, Dimethyl sulfoxide, Transdermal drug delivery.
Download: Request For Article
 












ONLINE SUBMISSION
USER LOGIN


Username
Password
Login | Register
News & Events
SCImago Journal & Country Rank

Terms and Conditions
Disclaimer
Refund Policy
Instrucations for Subscribers
Privacy Policy

Copyrights Form

0.12
2018CiteScore
 
8th percentile
Powered by  Scopus
Google Scholar

hit counters free