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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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RP-HPLC method for the simultaneous determination of mefenamic acid and drotaverine hydrochloride in tablet dosage form.

Author: UPLOADED BY-ADMIN, JIGNESH D. PATEL, BHAVIK A. PATEL, VIPUL M. VAGHELA, L. J. PATEL, P. U. PATEL
Abstract: A simple, specific, accurate and precise reverse phase high performance liquid chromatographic method was developed for the simultaneous estimation of mefenamic acid and drotaverine hydrochloride in tablet dosage form. A hypersil ODS-C18, 5 µm column 250 mm × 4.6 mm in isocratic mode, with mobile phase containing water, acetonitrile and methanol in proportion of 30:35:35 v/v/v, pH 2.25 adjusted with orthophosphoric acid were used. The flow rate was 1 ml/min, and effluent was monitored at 226 nm. The retention time of mefenamic acid and drotaverine hydrochloride were 11.41± 0.07 and 14.34 ± 0.05 min respectively, and the resolution factor was 3.0. Linearity range for mefenamic acid and drotaverine hydrochloride was 8-24 µg/ml. The limit of detection and limit of quantification for mefenamic acid was found to be 0.259 and 0.785 µg/ml respectively; and for drotaverine hydrochloride, 0.128 and 0.387µg/ml respectively. The proposed method is accurate, precise, specific and rapid for simultaneous estimation of mefenamic acid and drotaverine hydrochloride in tablet dosage form.
Keyword: Mefenamic acid, Drotaverine hydrochloride, RP-HPLC
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