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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Phytochemical, Anticholinesterase, Antipyretic and Antihistaminic activity of Leaves of Alangium salviifolium Linn.

Author: UPLOADED BY-ADMIN, ADESHINA GO, ONAOLAPO JA, EHINMIDU JO, ODAMA LE
Abstract: The present study reports the preliminary phytochemical, anticholinesterase, antipyretic and antihistaminic activity of leaves of the plant Alangium salviifolium. The shade dried powder of Alangium salviifolium (Family: Alangiaceae) was subjected to successive extraction using the solvents (Petroleum Ether, Chloroform, Ethanol and Water) in the increasing order of polarity. Thus the prepared extracts were subjected to the preliminary phytochemical analysis. The extracts were investigated for anticholinesterase activity in green frogs which was compared with standard drug Neostigmine (10mg/ml). The parameter measured for anticholinesterase activity was ciliary movement in frog’s buccal cavity and degree of contraction of frog’s rectus abdominis muscle and for antipyretic activity in albino rats which was compared with standard drug Paracetamol (100 mg/kg i.p.) and the parameter measured being rectal temperature. The antihistaminic activity was performed in guinea pigs and was compared with standard drug Chlorpheniramine maleate (10 mg/kg i.p.). The parameter measured being the resistance to dyspnoea and convulsions caused by histamine (1%). Results revealed that the ethanolic extract of the plant leaves showed significant anticholinesterase activity and ethanolic and aqueous extracts of the plant leaves showed less significant antipyretic activity at a dose of 300 µg and 300 mg/kg body weight. The ethanolic extract of the plant leaves did not reveal appreciable antihistaminic activity at the dose of 400 mg/kg body weight.
Keyword: Alangium salviifolium linn, Phytochemical, Anticholinesterase activity, Antipyretic activity, Antihistaminic activity.
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