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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Major Bioactive Metabolites of the Medicinal Mushroom: Ganoderma lucidum

Author: HOTAM CHAUDHARY, BALWANT SINGH PALIYA, SMRATI VERMA
Abstract: Ganoderma lucidum is a basidiomycetes white rot fungus belongs to the genus Ganoderma which has been used for medicinal purpose for centuries particularly in eastern countries like China, Japan & Korea. The basidiocarp, mycelia & spores of Ganoderma lucidum contain approximately 400 different bioactive compounds. The metabolites consist of mainly triterpenoids & polysaccharides & protiens. To date more than 140 triterpenoids & 200 polysaccharides have been isolated from different species Ganoderma. These compounds has been reported to have a number of pharmacological effects including immunomodulation, anti-atherosclerotic, anti-inflammatory, analgesic, chemopreventive, antitumor, chemo & radio protective, sleep promoting, antibacterial, antiviral (including anti-HIV), hypolipidemic, anti-fibrotic, hepatoprotective, anti-diabetic, anti-&rogenic, anti-angiogenic, anti-herpetic, antioxidative & radical-scavenging, anti-aging, hypoglycemic, estrogenic activity & anti-ulcer properties. The biological activities reported in Ganoderma lucidum, due to the wide range of structural diversity found in its metabolites. This review collates the publications which reported the different bioactive metabolites from this medicinal mushroom considering the most valid claim & research on biological activities of compounds.
Keyword: G.lucidum, Triterpenes, Polysachharides, Peptides
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0.12
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