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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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In vitro antioxidant and spasmolytic activity of piperine from piper longum

Author: MANISH PATEL, P. K. PATEL, D. P. S. YADAV, A. K. SETH,
Abstract: Piperine is important constituent of Piper longum Linn fruits. This study was carried out to study free radical scavenging activity, metal chelating activity, reducing power and spasmolytic activity of piperine. In DPPH scavenging activity, the IC50 values were found to be 363.3 and 177.3 µg/ml for piperine and ascorbic acid respectively. With H2O2 radical, ascorbic acid and piperine exhibited 50% scavenging activity at 164.26 and 289.16 µg/ml, respectively. Metal chelating activity of EDTA and piperine at 300 µg/ml is 93% and 61% respectively. Reducing power is also increase as concentration increases. Piperine also inhibits contraction induced by acetylcholine and BaCl2 on rat ileum. These results suggest piperine present in piper longum have significant antioxidant and spasmolytic activity.
Keyword: piperine, DPPD, H2O2, EDTA, spasmolytic
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0.12
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