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Microemulsion-Based Gel Formulation and Evaluation of Tretinoin for Topical Delivery.
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| Author:
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UPLOADED BY-ADMIN, A. M. SUTHAR1, J. D. MODI, M. P. PATEL, A. H. BARIA
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| Abstract:
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The purpose of this study was to investigate microemulsion-based gel (MBG) as a topical
delivery system for tretinoin (TRE) for the treatment of acne. Microemulsion was prepared by
mixing appropriate amount of surfactant like Span® 20, Span® 80, Tween® 20, Tween® 80
and co-surfactant like PEG 4000, octanol, PEG 6000 and then mixed with oily part like castor
oil, sunflower oil and olive oil. Then appropriate amount of drug was added and the final
mixture was mixed until a transparent solution was obtained. TRE loaded microemulsion was
slowly added to the viscous solution of carbomer 934 under magnetic stirring. The prepared
MBG were evaluated in terms of their droplet size, zeta potential, stability, in-vitro permeation
studies, and rheological properties. The phase study revealed that the maximum proportion of
oil was incorporated in microemulsion systems when the surfactant-to-cosurfactant ratio was
4:1. Formulations had small average droplet diameter range between 10 to 100 nm. Polydispersity
index (PI) was closer to zero that indicated about the homogenicity of the formulation.
Zeta potential of all microemulsion formulation was found between -7.02 to -0.044 mV. Optimized
formulation shows enhanced in-vitro permeation profile compare to commercial
cream. Optimized MBG formulation with stability and powerful permeation ability was expected
as a promising drug delivery system.
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| Keyword:
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Tretinoin, Microemulsions, Microemulsions Based Gel, Topical delivery.
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| EOI:
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| DOI:
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