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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Influence of Formulation Parameters on Famotidine Nanosuspension Produced By Nanoprecipitation Technique.

Author: UPLOADED BY-ADMIN, DHAVAL J. PATEL, DR. JAYVADAN K. PATEL, VIKRAM M. PANDYA1
Abstract: Low oral bioavailability of poorly water-soluble drugs poses a great challenge during drug development. Poorly water-soluble compounds are difficult to develop as drug products using conventional formulation techniques and are frequently abandoned early in discovery. The aim of the present study was to improve the dissolution rate of a poorly water-soluble drug, famotidine, by a nanoprecipitation technique. Selected parameters of the nanoprecipitation method, such as the amount of Lutrol F-68 (%) and stirring speed (rpm) were varied so as to obtain drug nanoparticles. The combination of lowest amount of stabilizer with low speed yield bluish white transparent nanosuspensions with the smallest average particle size (566 nm). In contrast to the very slow dissolution rate of pure famotidine, the nanosuspension of the drug considerably enhanced the dissolution rate. Nanosuspension prepared with 0.25% Lutrol F-68 with 1000 rpm showed the most improvement in dissolution rate of famotidine. The formulation of famotidine as a nanosuspension was very successful in enhancing dissolution rate, more than 42% of the drug being dissolved in the first 10 min (batch F1) compared to less than 2.5% of the micronized drug (batch F7).
Keyword: Famotidine, Poorly water-soluble drug, Nanoprecipitation, Drug Nanoparticles
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0.12
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