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Influence of Formulation Parameters on Famotidine Nanosuspension Produced By Nanoprecipitation Technique.
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| Author:
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UPLOADED BY-ADMIN, DHAVAL J. PATEL, DR. JAYVADAN K. PATEL, VIKRAM M. PANDYA1
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| Abstract:
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Low oral bioavailability of poorly water-soluble drugs poses a great challenge during drug
development. Poorly water-soluble compounds are difficult to develop as drug products using
conventional formulation techniques and are frequently abandoned early in discovery. The
aim of the present study was to improve the dissolution rate of a poorly water-soluble drug,
famotidine, by a nanoprecipitation technique. Selected parameters of the nanoprecipitation
method, such as the amount of Lutrol F-68 (%) and stirring speed (rpm) were varied so as to
obtain drug nanoparticles. The combination of lowest amount of stabilizer with low speed
yield bluish white transparent nanosuspensions with the smallest average particle size (566
nm). In contrast to the very slow dissolution rate of pure famotidine, the nanosuspension of
the drug considerably enhanced the dissolution rate. Nanosuspension prepared with 0.25%
Lutrol F-68 with 1000 rpm showed the most improvement in dissolution rate of famotidine.
The formulation of famotidine as a nanosuspension was very successful in enhancing dissolution
rate, more than 42% of the drug being dissolved in the first 10 min (batch F1) compared
to less than 2.5% of the micronized drug (batch F7).
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| Keyword:
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Famotidine, Poorly water-soluble drug, Nanoprecipitation, Drug Nanoparticles
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