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FORMULATION AND IN VITRO ASSESSMENT OF TRAZODONE MUCOADHESIVE TABLETS EMPLOYING NATURAL POLYMER GUM OLIBANUM
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| Author:
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ARTHAM PRIYA, PRAVEEN KUMAR MANTHENA, D.VARUN
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| Abstract:
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Trazodone is an imidazoline derivative, which acts as agonist on centrally located a2 receptors and this leads to myotonolytic effects on skeletal muscle. The aim of the work to develop mucoadhesive buccal tablets of Trazodone(TZD) were prepared by using Gum Olibanum and in combination of Gum Olibanum with sodium alginate as mucoadhesive polymers. Seven formulations were developed with varying concentrations of polymers. The prepared formulations were evaluated by various parameters. All the formulations displayed zero order release kinetics (‘r’ values from 0.9827 to 0.9951). Higuchi and Peppas data reveals that the drug released by non-Fickian diffusion mechanism. The in vitro release parameter values (t50%, t70%, and t90%) displayed by the various formulations range from 2.93 to 6.59 h (t50%), 4.97 to 7.96 h (t70%) and 7.34 to 7.48 h (t90%). The formulations TGG1, and TGG2 shows drug release 97.96%, and 96.17% within 8 h. FTIR studies show no evidence on interaction between drug polymers.
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| Keyword:
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Trazodonehydrochloride, Gum Olibanum, Sodium alginate, Mucoadhesive, Buccal tablets.
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| EOI:
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| DOI:
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