IJPR  articles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 0.13 (2013 - 2018).    

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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

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0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

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FORMULATION AND IN VITRO ASSESSMENT OF TRAZODONE MUCOADHESIVE TABLETS EMPLOYING NATURAL POLYMER GUM OLIBANUM

Author: ARTHAM PRIYA, PRAVEEN KUMAR MANTHENA, D.VARUN
Abstract: Trazodone is an imidazoline derivative, which acts as agonist on centrally located a2 receptors and this leads to myotonolytic effects on skeletal muscle. The aim of the work to develop mucoadhesive buccal tablets of Trazodone(TZD) were prepared by using Gum Olibanum and in combination of Gum Olibanum with sodium alginate as mucoadhesive polymers. Seven formulations were developed with varying concentrations of polymers. The prepared formulations were evaluated by various parameters. All the formulations displayed zero order release kinetics (‘r’ values from 0.9827 to 0.9951). Higuchi and Peppas data reveals that the drug released by non-Fickian diffusion mechanism. The in vitro release parameter values (t50%, t70%, and t90%) displayed by the various formulations range from 2.93 to 6.59 h (t50%), 4.97 to 7.96 h (t70%) and 7.34 to 7.48 h (t90%). The formulations TGG1, and TGG2 shows drug release 97.96%, and 96.17% within 8 h. FTIR studies show no evidence on interaction between drug polymers.
Keyword: Trazodonehydrochloride, Gum Olibanum, Sodium alginate, Mucoadhesive, Buccal tablets.
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Impact Factor for five years is 1.55 (2012 - 2016)

Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477