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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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RP-HPLC Method Development and Validation for Simultaneous Estimation of Montelukast Sodium and Levocetirizine Dihydrochloride.

Author: UPLOADED BY-ADMIN, S. ASHOKKUMAR, M.SENTHIL RAJA, .P. PERUMAL
Abstract: In this study, reverse phase high performance liquid chromatographic method have been developed and validated for the simultaneous determination of Montelukast and Levocetirizine in combined pharmaceutical formulation. HPLC separation was achieved with a Phenomenex – Luna, C18 (250 x 4.6 mm i.d., 5µ) as stationary phase and phosphate buffer (pH adjusted to 5.5 with dil. KOH): Acetonitrile (65:35, v/v) as eluent, at a flow rate of 1.5ml/min. UV detection was performed at 230 nm. The retention time of Montelukast and Levocetirizine were found to 3.7 and 6.1 min respectively. Results of the analysis were validated statistically and by recovery studies. The stability of Montelukast was maintained by carrying out all the operations in amber coloured glass wares with minimal exposure to light. The result of the studies showed that the proposed RP-HPLC method is simple, rapid, precise and accurate, which can be used for the routine determination of Montelukast and Levocetirizine in bulk and in its pharmaceutical dosage forms.
Keyword: Montelukast; Levocetirizine; HPLC; Assay.
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