*Five Years Citation in Google scholar (2016 - 2020) is. 1451*   *    IJPR IS INDEXED IN ELSEVIER EMBASE & EBSCO *       

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
ISSN
0975-2366
Current Issue
Article In Press
No Data found.
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
 

Article Detail

Label
Label
RP-HPLC Method Development and Validation for Simultaneous Estimation of Montelukast Sodium and Levocetirizine Dihydrochloride.

Author: UPLOADED BY-ADMIN, S. ASHOKKUMAR, M.SENTHIL RAJA, .P. PERUMAL
Abstract: In this study, reverse phase high performance liquid chromatographic method have been developed and validated for the simultaneous determination of Montelukast and Levocetirizine in combined pharmaceutical formulation. HPLC separation was achieved with a Phenomenex – Luna, C18 (250 x 4.6 mm i.d., 5µ) as stationary phase and phosphate buffer (pH adjusted to 5.5 with dil. KOH): Acetonitrile (65:35, v/v) as eluent, at a flow rate of 1.5ml/min. UV detection was performed at 230 nm. The retention time of Montelukast and Levocetirizine were found to 3.7 and 6.1 min respectively. Results of the analysis were validated statistically and by recovery studies. The stability of Montelukast was maintained by carrying out all the operations in amber coloured glass wares with minimal exposure to light. The result of the studies showed that the proposed RP-HPLC method is simple, rapid, precise and accurate, which can be used for the routine determination of Montelukast and Levocetirizine in bulk and in its pharmaceutical dosage forms.
Keyword: Montelukast; Levocetirizine; HPLC; Assay.
Download: Request For Article
 




ONLINE SUBMISSION
USER LOGIN


Username
Password
Login | Register
News & Events
SCImago Journal & Country Rank

Terms and Conditions
Disclaimer
Refund Policy
Instrucations for Subscribers
Privacy Policy

Copyrights Form

0.12
2018CiteScore
 
8th percentile
Powered by  Scopus
Google Scholar

hit counters free