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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Invivo Antioxidant Potential of Thespesia populnea Bark Extract against Mercury Induced Oxidative Stress

Author: RICHARD JAYARAJ, PRASANNARAJ GOVINDARAJ, RICHARD L. JAYARAJ, JOHN RAVINDAR D, NAMASIVAYAM ELANGOVAN
Abstract: The toxicity of the mercury in humans and animals is well established and this depends greatly on the mercuric compounds. In this study Thespesia populnea has been investigated for its possible protective role and which acts as a source of free radicals; in mercury induced cellular damage in Swiss albino mice. The liver marker enzymes SGPT and SGOT exhibited higher activity and the antioxidant enzymes CAT, GPx and GST results in lower activity in mercuric chloride [HgCl2] treated animals. Liver histopathology showed that Thespesia populnea bark extract had reduced fat cyst formation and developed binucleated cells induced by HgCl2 intoxication. From the results we conclude that enhanced levels of antioxidant enzymes and reduced amount of serum amino transaminase are responsible for the major protecting mechanisms of T. populnea bark extract in mercury induced oxidative stress in liver.
Keyword: Thespesia populnea, oxidative stress, mercury, antioxidant enzymes
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