IJPR  articles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 0.13 (2013 - 2018).    

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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

ISSN
0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

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Invivo Antioxidant Potential of Thespesia populnea Bark Extract against Mercury Induced Oxidative Stress

Author: RICHARD JAYARAJ, PRASANNARAJ GOVINDARAJ, RICHARD L. JAYARAJ, JOHN RAVINDAR D, NAMASIVAYAM ELANGOVAN
Abstract: The toxicity of the mercury in humans and animals is well established and this depends greatly on the mercuric compounds. In this study Thespesia populnea has been investigated for its possible protective role and which acts as a source of free radicals; in mercury induced cellular damage in Swiss albino mice. The liver marker enzymes SGPT and SGOT exhibited higher activity and the antioxidant enzymes CAT, GPx and GST results in lower activity in mercuric chloride [HgCl2] treated animals. Liver histopathology showed that Thespesia populnea bark extract had reduced fat cyst formation and developed binucleated cells induced by HgCl2 intoxication. From the results we conclude that enhanced levels of antioxidant enzymes and reduced amount of serum amino transaminase are responsible for the major protecting mechanisms of T. populnea bark extract in mercury induced oxidative stress in liver.
Keyword: Thespesia populnea, oxidative stress, mercury, antioxidant enzymes
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11th percentile
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Impact Factor for five years is 1.55 (2012 - 2016)

Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477