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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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: Drug Prescribing Pattern of Oral Antidiabetic Drugs and their Comparative Efficacy in Glycemic Control in Type-2 Diabetes Mellitus.

Author: RANGEEL RAINA, KAVITA DHAR , VIPENDER SINGH CHOPRA
Abstract: Background: Although clinical trials provide information on drug safety and efficacy of different life long treatment of Diabetes Mellitus(DM), however drug prescribing patterns and clinical efficacy may differ in different clinical set ups. Objectives: To study prescribing pattern of drugs in type II DM and efficacy of oral anti-diabetic regimen in terms of glycemic control, as well as to evaluate their cost efficacy. Methods: This observational study was conducted in newly diagnosed DM type II patients and was followed up for one year. A structured proforma was used to collect information from their prescriptions. Results: Out of total 150 type II DM patients, most of patients (78.66%) were of age group of 35-64 years. Mean number of drugs per prescription was 1.83±1.31. A total of 245 hypoglycemic drugs were prescribed and these accounted for 52 % of all drugs prescribed. Oral anti-diabetic agents were advised in 80.70 %. Amongst the oral, biguanides were most frequently prescribed (48.80%), followed by sulphonylureas (37.60 %) and Thiazolidinediones (8%). Single, two and three oral agents were prescribed in 43.8%, 40.6%, 15.6 % of patients, respectively. Oral antidiabetic - insulin combination was found in 6 % and 4.5% received not any antidiabetic agent. Glycemic control was achieved in 81.81% of patients on combination therapy of biguanides and sulphonylureas. This combination therapy was found significantly efficacious (p< 0.001) than monotherapy. Conclusion: High frequency of polytherapy with oral antidiabetic drugs is consistent with fact that new trends in treatment of type II DM has emerged, proving combination therapy to be more effective than monotherapy.
Keyword: Type II diabetes mellitus, antidiabetic, polytherapy, observational
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