IJPR  articles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 0.13 (2013 - 2018).    

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
Current Issue
Article In Press
No Data found.
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
 

Article Detail

Label
Label
Hydrotropic Solubilisation and its Effect on the Solid Dispersion of Famotidine

Author: UPLOADED BY-ADMIN, S. PUNITHA, SOUJANYA. P, G. RAJIYA BEGUM, T. GOWTHAM, S. RAJASEKAR
Abstract: Famotidine is the anti ulcer drug showing only 20-30% bioavailability with short half life (2.5-4 h) and possess low aqueous solubility (0.75 mg/ml). The aim of the study was to improve the aqueous solubility of famotidine by hydrotropic solubilisation technique and to evaluate the effect of hydrotropes in solid dispersion of famotidine. In hydrotropic solubilisation, the famotidine solubility was determined in sodium salicylate, urea and tri sodium citrate dihydrate at different concentrations and the drug contents were determined by UV spectrophotometer. The solubility of famotidine was significant in 1M hydrotropic solution in the following order, sodium salicylate (2.39 mg/ml), urea (1.05 mg/ml) and tri sodium citrate dihydrate (0.26 mg/ml). The solid dispersion was prepared at 1:1, 1:3 and 1:5 ratio of famotidine : hydrotrope [sodium salicylate (S1, S2, S3), urea(U1, U2, U3) and tri sodium citrate dihydrate (T1, T2, T3) and was subjected to evaluation for its loss on drying, drug content, in-vitro release study and stability. The loss on drying was 0.030 % to 1.310 %, drug content was 90±7.43 % and was found to be stable. The in-vitro drug release was found to be 98.6 % and 99.8% at 2 min for S2 and S3 where as for the marketed product it was found to be 73.37% at 45 min. As the aqueous solubility of famotidine was more in sodium salicylate its solid dispersion shows significant improvement in dissolution as compared to marketed formulation.
Keyword: Famotidine, Hydrotropy, solid dispersion, sodium salicylate.
Download: Request For Article
 












ONLINE SUBMISSION
USER LOGIN


Username
Password
Login | Register
News & Events

Terms and Conditions
Disclaimer
Refund Policy
Instrucations for Subscribers
Privacy Policy

Copyrights Form

0.12
2018CiteScore
 
8th percentile
Powered by  Scopus
Google Scholar

hit counters free