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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Analytical Method Development And Validation of Acetaminophen, Caffeine, Phenylephrine Hydrochloride, Dextromethorphan Hydrobromide and Chlorpheniramine Maleate In Tablet Dosage Form By Rp- Hplc

Author: GYANENDRA PATEL, PALLED M. S, BHAT A. R, PATEL GYANENDRA SINGH, MANE ARUNA
Abstract: A simple, selective, rapid, precise and economical RP HPLC method has been developed for the determination of Acetaminophen, Caffeine, Phenylephrine Hydrochloride, Dextromethorphan Hydrobromide and Chlorpheniramine Maleate in tablet formulation. The analysis was resolved by using a gradient mobile phase (Sodium salt of heptane sulphonic acid buffer solution and acetonitrile ) at a flow rate of 1ml/min on an gradient consisting of Agilent 1200 LC HPLC system on variable wavelength UV detector using, Inertsil C8 (4.6 mm x 15 cm, 5 µm) column at a wavelength of 214 nm. The retention time were found to be Acetaminophen (4 min), Caffeine (5 min), Phenylephrine HCl (7 min), Dextromethorphan HBr (14 min) and Chlorpheniramine maleate (13 min). The percent recovery of Acetaminophen, Caffeine, Phenylephrine Hydrochloride, Dextromethorphan Hydrobromide and Chlorpheniramine maleate were found to be in between 98% to 102%. The developed method was simple, precise, accurate and reproducible and therefore suitable for routine analysis of drugs in tablet dosage form.
Keyword: Acetaminophen, Caffeine, Phenylephrine HCL, Dextromethorphan HBr and Chlorpheniramine maleate.
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0.12
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