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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Development, Characterization and In-vitro Evaluation of Aspirin loaded Solid Lipid Nanoparticles (SLNs) for effective treatment of Rheumatoid Arthritis

Author: KIRAN DESHPANDE
Abstract: In present study, Optimization and formulation design were done by using factorial design software (Design Expert 8.0.7.1, Statease, USA). Response surface plots and main effect plots were utilised to study effect of variables on the response parameters. Aspirin (ASP) loaded Solid lipid nanoparticles (SLNs) were prepared using optimised process parameters and by microemulsion method using melted Glyceryl monosterate (GMS) as an oil phase and Poloxomer407 water solution as an aqueous phase. Formulated ASP-SLNs were characterised for particle size, polydispersity index, zeta potential, drug entrapment efficiency, in-vitro drug release, differential scanning calorimetry (DSC), scanning electron microscopy (SEM) and for stability studies. Among all formulations SLN5 was found to be an optimized formulation on the basis of small particle size 52.10 nm, higher entrapment efficiency 88.40%, and higher in vitro cumulative drug release 79.14%. DSC studies reveals that aspirin was stable in final formulation and compatibility with selected excipients in the formulation. Formulated SLNs loaded ASP nanoparticles can be deliver through oral, parenteral or topical routes for improvement of bioavailability and to avoid GI side effects of ASP.
Keyword: Solid lipid nanoparticles (SLNs), Aspirin (ASP), Microemulsion, Glyceryl monosterate (GMS), Differential scanning calorimetry (DSC).
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