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Development and Evaluation of Antifreeze Intramuscular Injection of Atropine Sulphate
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| Author:
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LOKENDRA SINGH
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| Abstract:
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Antifreeze injection is the basic need for army forces in cold climate region where temperature falls down up to -130C. In the battle field for avoiding organophosphate poisoning atropine sulphate is used in emergency condition. Organophosphate poisoning is caused by exposure to insecticides like Malathion, Parathion, Dimethoate, Diazinon, Methamidophos and Monocrotophos and agents of chemical warfare. Mass poisoning can occur during chemical warfares and nerve gas agent attack of gases like sarin, suman, tabun etc. After the intravenous injection intramuscular injection gives second fastest route of administration on the basis of response of the drugs. There is no need of trained paramedical staff for intramuscular injection as this injection is available as auto injectors. In the formulation of antifreeze intramuscular injection there is no any significant change of the release profile of atropine sulphate by In-vitro study between control and optimized formulation. Repeated freezing and thawing can cause the possibility of drug degradation and some physical and chemical changes since after one time freezing U.V. absorbance decreases. In-vitro release study control group has 97.9% and optimized formulation has 96.88% release of the drug.
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| Keyword:
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Atropine sulphate, glycerol, Ethanol, Depression in freezing point.
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| EOI:
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-
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| DOI:
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-
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| Download:
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