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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

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Studies on Poloxamer Based Mucoadhesive Ophthalmic In Situ Hydrogel of Moxifloxacin HCl.

Author: UPLOADED BY-ADMIN, D. H. SHASTRI, S. T. PRAJAPATI, R. K. PARIKH, L. D. PATEL
Abstract: Conventional eye drops shows relatively low bioavailability due to poor precorneal contact time. In situ hydrogels are of great importance in providing sustained ocular drug delivery due to their elastic properties hydrogels resist ocular drainage leading to longer contact times. In the present study an in situ gelling thermoreversible mucoadhesive gel was formulated of an antibacterial agent Moxifloxacin HCl using combination of poloxamer 407 and poloxamer 188 with different mucoadhesive polymers such as Gelrite, Xanthan gum and Sodium alginate with a view to increase in gel strength and bioadhesion force and thereby increase in precorneal contact time and there by increase in bioavailability of the drug. The formulations were evaluated for physical parameters like Clarity, pH, drug content, gelation temperature, gel strength, bioadhesion force and in vitro drug release study. The formulated gels were transparent, uniform in consistency and had spreadability with a pH range of 6.8 to 7.4. A satisfactory bioadhesion on the sheep's corneal surface and good gel strength were also observed. As the concentration of mucoadhesive polymers in the gel formulation increases, the rate of drug release decreases. The order of drug release was Xanthan gum>Sodium alginate> Gelrite. Amongst the polymers selected Gelrite showed satisfactorily higher gel strength, bioadhesion force and sustained drug release profile for more than ten hours time period and found stable throughout the stability period. Thus it can be concluded that the Gelrite was more suitable for combining with poloxamers for the formulation of ophthalmic in situ gelling system for sustained ocular drug delivery of Moxifloxacin HCl, which cannot only reduce the individual polymer concentrations but also improves the bioavailability of the drugs on the precorneal area.
Keyword: Ophthalmic Hydrogel, Moxifloxacin HCl, Poloxamer 407, Bioadhesive polymers,Gelrite.
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