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Studies on Poloxamer Based Mucoadhesive Ophthalmic In Situ Hydrogel of Moxifloxacin HCl.
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| Author:
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UPLOADED BY-ADMIN, D. H. SHASTRI, S. T. PRAJAPATI, R. K. PARIKH, L. D. PATEL
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| Abstract:
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Conventional eye drops shows relatively low bioavailability due to poor precorneal
contact time. In situ hydrogels are of great importance in providing sustained ocular drug delivery
due to their elastic properties hydrogels resist ocular drainage leading to longer contact
times. In the present study an in situ gelling thermoreversible mucoadhesive gel was formulated
of an antibacterial agent Moxifloxacin HCl using combination of poloxamer 407 and
poloxamer 188 with different mucoadhesive polymers such as Gelrite, Xanthan gum and Sodium
alginate with a view to increase in gel strength and bioadhesion force and thereby increase
in precorneal contact time and there by increase in bioavailability of the drug. The
formulations were evaluated for physical parameters like Clarity, pH, drug content, gelation
temperature, gel strength, bioadhesion force and in vitro drug release study. The formulated
gels were transparent, uniform in consistency and had spreadability with a pH range of 6.8 to
7.4. A satisfactory bioadhesion on the sheep's corneal surface and good gel strength were also
observed. As the concentration of mucoadhesive polymers in the gel formulation increases,
the rate of drug release decreases. The order of drug release was Xanthan gum>Sodium alginate>
Gelrite. Amongst the polymers selected Gelrite showed satisfactorily higher gel
strength, bioadhesion force and sustained drug release profile for more than ten hours time
period and found stable throughout the stability period. Thus it can be concluded that the Gelrite
was more suitable for combining with poloxamers for the formulation of ophthalmic in
situ gelling system for sustained ocular drug delivery of Moxifloxacin HCl, which cannot only
reduce the individual polymer concentrations but also improves the bioavailability of the
drugs on the precorneal area.
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| Keyword:
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Ophthalmic Hydrogel, Moxifloxacin HCl, Poloxamer 407, Bioadhesive polymers,Gelrite.
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| DOI:
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