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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

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0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

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Preparation And Elvaution Of Thermally Cross-Linked Chitosan Clarithromycin Mucoadhesive Microspheres

Author: UPLOADED BY-ADMIN, H. D. KORADIA, V. A. PATEL, H. V. PATEL, K. N. PATEL
Abstract: Clarithromycin, an effective antibiotic, for the eradication of H. pylori. Clarithromycin requires mucoadhesive controlled release formulation owing to short residence time of the conventional dosage form in the stomach. Chitosan is one of the polysaccharides which show antimicrobial and bio compatible behavior. Chitosan obtained by deacetylation of chitin (a naturally occurring polymer) has been shown to possess mucoadhesive properties owing to the molecular attractive forces formed by electrostatic interaction between positively charged chitosan and negatively charged mucosal surfaces. Mucoadhesive chitosan micro spheres of Clarithromycin were prepared by thermal crosslinking in presence of citric acid at high temperature. Formulations were characterized for percentage yield, particle size, surface morphology, percent drug content, swelling kinetics, in vitro mucoadhesion and in vitro drug release. Microspheres were discrete, spherical, free flowing and of larger particle size. Percent yield of microspheres was varied from 58.01 to 75 %. Percentage drug content was varied from 4.097 to 14.77 %. Percentage drug content was increased with increase in drug concentration. Smaller size microspheres (370 µm) were obtained when drug concentration was lower (1:4 D/P ratio). Swelling index and Percentage mucoadhesion were decrease as the D/P ratio was increased. Clarithromycin release from chitosan microspheres was characterized by an initial rapid release of drug followed by a slow release.
Keyword: Clarithromycin, Chitosan, H. pylori, Mucoadhesive micro spheres
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