IJPR  articles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 0.13 (2013 - 2018).    

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
Current Issue
No Data found.
Article In Press
No Data found.
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
 

Article Detail

Label
Label
Preparation And Elvaution Of Thermally Cross-Linked Chitosan Clarithromycin Mucoadhesive Microspheres

Author: UPLOADED BY-ADMIN, H. D. KORADIA, V. A. PATEL, H. V. PATEL, K. N. PATEL
Abstract: Clarithromycin, an effective antibiotic, for the eradication of H. pylori. Clarithromycin requires mucoadhesive controlled release formulation owing to short residence time of the conventional dosage form in the stomach. Chitosan is one of the polysaccharides which show antimicrobial and bio compatible behavior. Chitosan obtained by deacetylation of chitin (a naturally occurring polymer) has been shown to possess mucoadhesive properties owing to the molecular attractive forces formed by electrostatic interaction between positively charged chitosan and negatively charged mucosal surfaces. Mucoadhesive chitosan micro spheres of Clarithromycin were prepared by thermal crosslinking in presence of citric acid at high temperature. Formulations were characterized for percentage yield, particle size, surface morphology, percent drug content, swelling kinetics, in vitro mucoadhesion and in vitro drug release. Microspheres were discrete, spherical, free flowing and of larger particle size. Percent yield of microspheres was varied from 58.01 to 75 %. Percentage drug content was varied from 4.097 to 14.77 %. Percentage drug content was increased with increase in drug concentration. Smaller size microspheres (370 µm) were obtained when drug concentration was lower (1:4 D/P ratio). Swelling index and Percentage mucoadhesion were decrease as the D/P ratio was increased. Clarithromycin release from chitosan microspheres was characterized by an initial rapid release of drug followed by a slow release.
Keyword: Clarithromycin, Chitosan, H. pylori, Mucoadhesive micro spheres
Download: Request For Article
 












ONLINE SUBMISSION
USER LOGIN


Username
Password
Login | Register
News & Events
SCImago Journal & Country Rank

Terms and Conditions
Disclaimer
Refund Policy
Instrucations for Subscribers
Privacy Policy

Copyrights Form

0.12
2018CiteScore
 
8th percentile
Powered by  Scopus
Google Scholar

hit counters free