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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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A 28 DAYS SUB-ACUTE TOXICITY STUDY OF METFORMIN AND PIOGLITAZONE COMBINATION IN SPRAGUE DAWLEY RATS

Author: NEHA THAKOR
Abstract: Diabetes mellitus describes a metabolic disorder of multiple etiology characterized by chronic hyperglycemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action or both. Metformin and Pioglitazone is used in type2 DM, falls in the class of biguanide and thiazolidonediones. Sub acute study was undertaken with the objective to provide information on major toxicity of the combination of metformin and pioglitazone, by performing 28-days oral toxicity study on Sprague Dawley rats. Dose selection was based MRHD for both drug. In this study, control group was administered with vehicle groups II and III were administered with the metformin at525mg/kg and 1050mg/kg doses respectively, while groups IV and V were administered with pioglitazone at 30mg/kg and 60mg/kg doses respectively, groups VI and VII were co-administered with both drugs metformin & pioglitazone at low and at high doses respectively, for 28 days by oral administration. This study establish that both metformin and pioglitazone are non-toxic in rats following oral administration.
Keyword: Diabetes mellitus, Metformin, Pioglitazone, Toxicity
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0.12
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