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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

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0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

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QSAR analysis of oxidiazole benzene sulfonamide derivative as ?3-adrenergic receptor agonist

Author: UPLOADED BY-ADMIN, D. PATEL, N. M. PATEL
Abstract: To establish QSAR between physicochemical descriptor and ?3-adrenergic receptor agonist of oxadiazole benzene sulfonamide. Computational chemistry based Insilico method. ?3 adrenergic receptor is considered as one of the potential target for obesity therapy involving thermogenesis process in brown adipose tissue. Biological data were divided in to four classes on activity basis, and training and test set was selected by considering all class of molecule. Several significant equations with good co-efficient (r2>0.7) of correlation were obtained; the final model was selected based on forward selection of molecular descriptor. Good QSAR correlation established with r2 = 0.841 and it is statistically significant The final model is able to predict activity accurately for active compounds of the test set series and was further cross validated. QSAR model developed here is statistically significant and can be utilize in further optimizing the series for further development.
Keyword: QSAR, benzene sulphonamide, Agonist, obesity, ?3 adrenergic receptor
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