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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Formulation, Evaluation and Optimization of Transdermal Drug Delivery System using Different Ratio of Eudragit RL100/RS100 for Disease Modifying Antirheumatic Drugs.

Author: UPLOADED BY-ADMIN, NIRAV A. SINGHAL, GIRISH K. JANI, ANIL BHANDARI, S. M. VIJAYENDRASWAMY, NISHANT UPADHYAY
Abstract: Transdermal patches of Methotrexate were prepared by solvent casting method using Di-Butyl n- phthalate and Eudragit RL100: Eudragit RS100 in different ratios. Methotrexate containing transdermal patches were formulated by using central composite design having 2 independent variables at 3 levels. Independent variables were total amount of polymers (X1) and % of Eudragit RS100 (X2). The prepared formulations were evaluated for various physicochemical properties like flexibility, thickness, smoothness, weight variation and tensile strength were evaluated and found to be flexible, uniform thickness and weight, smooth and good drug content (97.4 to 99.9 %). The prepared formulations were also evaluated for invitro drug release as well as ex-vivo drug diffusion characteristics. Statistical Optimization carried out for various responses like ‘K’ of zero order, T50% and T80%. Optimized Formulation was found to provide more controlled diffusion of drug. Release kinetics of Optimized Formulation followed zero order drug diffusion. Hence Optimized Transdermal Patch could be a promising delivery system for Methotrexate with controlled release action and improved drug availability.
Keyword: Central composite design, Transdermal Patch, Methotrexate, Eudragit polymers.
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