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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Formulation and In Vitro Evaluation of Mouth Dissolving Tablet of Olanzapine Using Solid Dispersion Technique

Author: UPLOADED BY-ADMIN, V. G. BRAHMBHATT, M. R. PATEL
Abstract: In the present investigation solid dispersion of olanzapine has been prepared to improve its solubility and dissolution profile. Further, using solid dispersion, mouth dissolving tablet was prepared to overcome the problem of swallowing for patient compliance. Solid dispersion was prepared in different drug:carrier ratio like 1:3, 1:5, 1:10 with Polyvinylpyrrolidone k-30 using solvent evaporation technique. Prepared solid dispersion was characterized for saturation solubility, in vitro drug release, X-ray diffraction, differential scanning calorimetry, gas chromatography and Fourier Transform Infra-Red analysis. A Simplex-Lattice design was applied to investigate the combine effect of three factors, i.e. superdisintegrants like croscarmellose sodium(X1) crospovidone(X2), and sodium starch glycolate(X3) in tablet formulation. Disintegration time and T50 (Time required to 50% drug release) taken as responses. The prepared tablets were evaluated for hardness, friability, disintegration time, wetting time, water absorption ratio, estimation of drug content and in vitro drug release studies. Solid dispersion with a drug-carrier ratio of 1:5 showed highest solubility in comparison with other samples. Saturation solubility results verified the solubilization effect of the carrier. X-ray diffraction analysis confirmed the reduction of crystallinity. Differential scanning calorimetry analysis revealed complete dispersion of olanzapine into carrier Polyvinylpyrrolidone k-30. IR analysis substantiated the inertness of the carrier. Gas chromatography analysis confirmed complete absence of chloroform. For mouth dissolving tablet, results of simplex lattice design showed that batch O1 containing 5% croscarmellose sodium alone had minimum disintegration time (44 sec.) and faster drug release (T50: 40 sec) compared to other batches.
Keyword: Olanzapine, solid dispersion, solubility, mouth dissolving tablet, disintegration
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