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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Development and Validation of RP-HPLC Method for the Quantitative Estimation of Dorzolamide Hydrochloride in Ophthalmic Solution

Author: UPLOADED BY-ADMIN, C. BALA KUMAR, M. KARPAKAVALLI, B. LAKSHMI NARAYANAN, T. LINGARAJ, E. P. KUMAR
Abstract: Simple and sensitive method for the quantification of Dorzolamide hydrochloride in ophthalmic solution by RP-HPLC has been developed. Isocratic separation of Dorzolamide hydrochloride was carried out using a reversed-phase column C18 (150 × 4.6 mm, 5 µm) with mobile phase consisting of methanol and buffer (pH adjusted to 3 with glacial acetic acid) in the ratio 55:45 (v/v) and quantified by UV detection at 254 nm. Analytical run time was 12 min with retention time of 3.5 min. The assay exhibited good linear relationship accuracy and precision were over the concentration level form 50% to 150%. This method can be used for routine analysis of Dorzolamide hydrochloride in ophthalmic solution.
Keyword: HPLC, validation, Dorzolamide hydrochloride, ophthalmic formulation
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