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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Formulation and Evaluation of Guar Gum Glipizide Microspheres for Oral Controlled Release Drug Delivery

Author: UPLOADED BY-ADMIN, SOMADAS ROY, K. M. MANJANNA
Abstract: The successful optimization and development of drug entity, design of dosage form then plays important role. In the present research work, guar gum microspheres containing glipizide were prepared by emulsification cross-linking method using polyvinyl alcohol coating polymer and glutaraldehyde as a cross-linking agent. No significant drug-polymer interactions and physical state of the drug in the formulation were observed by Fourier infrared spectroscopy and differential scanning calorometry. The shape and surface characteristics were determined by scanning electron microscopy. Particle size distribution was determined by standard sieve analysis. Particle size, shape and surface morphology, swelling ratio, drug entrapment efficiency and in-vitro release were significantly affected by concentration of guar gum and glutaraldehyde. The drug entrapment efficiency was obtained in the range of 81.30-94.24 %w/v. In-vitro drug release profile glipizide from microbeads was examined in simulated intestinal pH 7.4 at end of 12h. The mechanism of drug release from guar gum and polyvinyl alcohol microspheres was diffusion controlled followed by First order kinetics and whereas coated microspheres approaching to near Zero- order kinetics.
Keyword: Glipizide, Guar gum, polyvinyl alcohol, emulsification, Glutaraldehyde, Zero-order kinetics.
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