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Formulation and Evaluation of Guar Gum Glipizide Microspheres for Oral Controlled Release Drug Delivery
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| Author:
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UPLOADED BY-ADMIN, SOMADAS ROY, K. M. MANJANNA
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| Abstract:
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The successful optimization and development of drug entity, design of dosage form then plays important role. In the
present research work, guar gum microspheres containing glipizide were prepared by emulsification cross-linking method
using polyvinyl alcohol coating polymer and glutaraldehyde as a cross-linking agent. No significant drug-polymer
interactions and physical state of the drug in the formulation were observed by Fourier infrared spectroscopy and differential
scanning calorometry. The shape and surface characteristics were determined by scanning electron microscopy. Particle size
distribution was determined by standard sieve analysis. Particle size, shape and surface morphology, swelling ratio, drug
entrapment efficiency and in-vitro release were significantly affected by concentration of guar gum and glutaraldehyde. The
drug entrapment efficiency was obtained in the range of 81.30-94.24 %w/v. In-vitro drug release profile glipizide from
microbeads was examined in simulated intestinal pH 7.4 at end of 12h. The mechanism of drug release from guar gum and
polyvinyl alcohol microspheres was diffusion controlled followed by First order kinetics and whereas coated microspheres
approaching to near Zero- order kinetics.
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| Keyword:
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Glipizide, Guar gum, polyvinyl alcohol, emulsification, Glutaraldehyde, Zero-order kinetics.
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| EOI:
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| DOI:
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