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An Alternative and Efficient Synthesis of Olmesartan Medoxomil via Suzuki coupling
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| Author:
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UPLOADED BY-ADMIN, NARENDER RAO SOMISETTI, T. RAVISANKAR, K. SUDHAKAR BABU
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| Abstract:
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An efficient synthesis of angiotension II receptor antagonist Olmesartan medoxomil (Benicar ®) is presented. The
Suzuki cross coupling of 5-phenyl-1-benzyl-1H-tetrazolyl boronic acid (7) with aryl bromide (8) followed by ester
hydrolysis is the key step (82 %) of the synthesis. This route overcomes the drawbacks of the previously reported synthesis.
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| Keyword:
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Antihypertensive therapy; Aryl bromide; Suzuki coupling; Tetrazole and Olmesartan Medoxomil
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| EOI:
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| DOI:
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