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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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An Alternative and Efficient Synthesis of Olmesartan Medoxomil via Suzuki coupling

Author: UPLOADED BY-ADMIN, NARENDER RAO SOMISETTI, T. RAVISANKAR, K. SUDHAKAR BABU
Abstract: An efficient synthesis of angiotension II receptor antagonist Olmesartan medoxomil (Benicar ®) is presented. The Suzuki cross coupling of 5-phenyl-1-benzyl-1H-tetrazolyl boronic acid (7) with aryl bromide (8) followed by ester hydrolysis is the key step (82 %) of the synthesis. This route overcomes the drawbacks of the previously reported synthesis.
Keyword: Antihypertensive therapy; Aryl bromide; Suzuki coupling; Tetrazole and Olmesartan Medoxomil
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0.12
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8th percentile
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